Short-term inhalation study of graphene oxide nanoplates.
Short-term inhalation study of graphene oxide nanoplates.
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DOI：
10.1080/17435390.2018.1431318
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发表时间：
2018-04
期刊：
影响因子：
5
通讯作者：
Yu IJ
中科院分区：
文献类型：
--
作者：
Kim YH;Jo MS;Kim JK;Shin JH;Baek JE;Park HS;An HJ;Lee JS;Kim BW;Kim HP;Ahn KH;Jeon K;Oh SM;Lee JH;Workman T;Faustman EM;Yu IJ
氧化石墨烯具有独特的物理化学性质，在电子、制药和医学领域具有重要的潜在应用。然而，吸入氧化石墨烯后的毒性尚未得到澄清。因此，本研究使用纯鼻吸入暴露系统和雄性Sprague-Dawley大鼠进行了短期氧化石墨烯吸入毒性分析。随机分为4组（每组15只）：(1)对照组（新鲜空气）、(2)低浓度（0.76±0.16 mg/m3）、(3)中浓度（2.60±0.19 mg/m3）、(4)高浓度（9.78±0.29 mg/m3）。大鼠连续5天每天暴露于氧化石墨烯6小时，随后恢复1、3和21天。短期暴露后或恢复期没有发现明显的身体或器官重量变化。同样，在氧化石墨烯暴露后或暴露后观察期间的血液学分析、支气管肺泡灌洗液（BAL）炎症标志物、BAL液体细胞因子或血液生化分析中，也没有发现显著的系统性毒理学影响。此外，在淋巴细胞、巨噬细胞或多形核细胞等BAL细胞差异中，未观察到显著差异。从1天到21天，在所有浓度组的肺中观察到氧化石墨烯摄入的肺泡巨噬细胞作为自发清除反应。肝脏和肾脏的组织病理学检查未发现任何显著的与试验相关的组织病理学病变。重要的是，与之前报道的石墨烯吸入数据相似，这项仅通过鼻子吸入的短期研究发现，氧化石墨烯对肺部和其他器官的毒性很小或不明显。
Graphene oxides possess unique physicochemical properties with important potential applications in electronics, pharmaceuticals, and medicine. However, the toxicity following inhalation exposure to graphene oxide has not yet been clarified. Therefore, this study conducted a short-term graphene oxide inhalation toxicity analysis using a nose-only inhalation exposure system and male Sprague-Dawley rats. A total of four groups (15 rats per group) were exposed: (1) control (fresh air), (2) low concentration (0.76 ± 0.16 mg/m3), (3) moderate concentration (2.60 ± 0.19 mg/m3), and (4) high concentration (9.78 ± 0.29 mg/m3). The rats were exposed to graphene oxide for 6 h/day for 5 days, followed by recovery for 1, 3, and 21 days. No significant body or organ weight changes were noted after the short-term exposure or during the recovery period. Similarly, no significant systemic effects of toxicological importance were noted in the hematological assays, bronchoalveolar lavage fluid (BAL) inflammatory markers, BAL fluid cytokines, or blood biochemical assays following the graphene oxide exposure or during the post-exposure observation period. Moreover, no significant differences were observed in the BAL cell differentials, such as lymphocytes, macrophages, or polymorphonuclear cells. Graphene oxide-ingested alveolar macrophages as a spontaneous clearance reaction were observed in the lungs of all the concentration groups from post 1 day to post 21 days. Histopathological examination of the liver and kidneys did not reveal any significant test-article-relevant histopathological lesions. Importantly, similar to previously reported graphene inhalation data, this short-term nose-only inhalation study found only minimal or unnoticeable graphene oxide toxicity in the lungs and other organs.
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影响因子：
16.6
作者：
Balapanuru, Janardhan;Yang, Jia-Xiang;Loh, Kian Ping
通讯作者：
Loh, Kian Ping
影响因子：
10
作者：
Ma-Hock L;Strauss V;Treumann S;Küttler K;Wohlleben W;Hofmann T;Gröters S;Wiench K;van Ravenzwaay B;Landsiedel R
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影响因子：
2.1
作者：
Ma-Hock, Lan;Burkhardt, Silke;Landsiedel, Robert
通讯作者：
Landsiedel, Robert
影响因子：
3.7
作者：
Bengtson S;Knudsen KB;Kyjovska ZO;Berthing T;Skaug V;Levin M;Koponen IK;Shivayogimath A;Booth TJ;Alonso B;Pesquera A;Zurutuza A;Thomsen BL;Troelsen JT;Jacobsen NR;Vogel U
通讯作者：
Vogel U
影响因子：
10
作者：
Roberts JR;Mercer RR;Stefaniak AB;Seehra MS;Geddam UK;Chaudhuri IS;Kyrlidis A;Kodali VK;Sager T;Kenyon A;Bilgesu SA;Eye T;Scabilloni JF;Leonard SS;Fix NR;Schwegler-Berry D;Farris BY;Wolfarth MG;Porter DW;Castranova V;Erdely A
通讯作者：
Erdely A