Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis.
Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis.
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DOI：
10.1136/ard.2009.122739
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发表时间：
2010-07
影响因子：
27.4
通讯作者：
Mikuls TR
中科院分区：
文献类型：
--
作者：
Miriovsky BJ;Michaud K;Thiele GM;O'Dell JR;Cannon GW;Kerr G;Richards JS;Johnson D;Caplan L;Reimold A;Hooker R;Mikuls TR
To examine associations of anti-cyclic citrullinated peptide antibody (aCCP) and rheumatoid factor (RF) concentrations with future disease burden in patients with rheumatoid arthritis (RA). Outcome measures were examined in U.S. veterans with RA and included: 1) proportion of observation in remission (Disease Activity Score [DAS]28 ≤ 2.6), 2) remission for ≥ 3 consecutive months, and 3) area under the curve [AUC] for DAS28. Associations of autoantibody concentration (per 100 unit increments) with outcomes were examined using multivariate regression. Patients (n = 855) were predominantly men (91%) with mean (SD) age of 66 (11) years and 2.3 (1.2) years of follow-up. Most were aCCP (75%) and RF (80%) positive. After multivariate adjustment, aCCP (OR 0.93; 95% CI 0.91-0.96) and RF concentrations (OR 0.92; 95% CI 0.90-0.95) were associated with a lower odds of remission, a lower proportion of observation in remission (p = 0.054 and p = 0.014, respectively), and greater AUC DAS28 (p = 0.05 and p = 0.002, respectively). In aCCP+ / RF- patients, higher aCCP concentrations were associated with an increased likelihood of remission (OR 1.10; 95% CI 1.00-1.20). Among aCCP- / RF+ patients, higher RF concentrations trended towards an inverse association with remission (OR 0.81; 95% CI 0.58-1.13). aCCP concentrations (particularly in RF positive patients) are associated with poor prognosis in U.S. veterans with RA. Analyses of autoantibody discordant patients suggest that RF concentrations may be a stronger predictor of disease burden than aCCP concentration.
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影响因子：
4.9
作者：
van der Helm-van Mil AH;Verpoort KN;Breedveld FC;Toes RE;Huizinga TW
通讯作者：
Huizinga TW
影响因子：
27.4
作者：
Forslind, K;Ahlmén, M;Svensson, B
通讯作者：
Svensson, B
影响因子：
--
作者：
Jawaheer, Damini;Lum, Raymond F.;Criswell, Lindsey A.
通讯作者：
Criswell, Lindsey A.
影响因子：
27.4
作者：
Berglin, E;Johansson, T;Rantapää-Dahlqvist, S
通讯作者：
Rantapää-Dahlqvist, S
影响因子：
4.9
作者：
Sokka T;Toloza S;Cutolo M;Kautiainen H;Makinen H;Gogus F;Skakic V;Badsha H;Peets T;Baranauskaite A;Géher P;Ujfalussy I;Skopouli FN;Mavrommati M;Alten R;Pohl C;Sibilia J;Stancati A;Salaffi F;Romanowski W;Zarowny-Wierzbinska D;Henrohn D;Bresnihan B;Minnock P;Knudsen LS;Jacobs JW;Calvo-Alen J;Lazovskis J;Pinheiro Gda R;Karateev D;Andersone D;Rexhepi S;Yazici Y;Pincus T;QUEST-RA Group
通讯作者：
QUEST-RA Group