Performance comparison of dual-ended readout depth-encoding PET detectors based on BGO and LYSO crystals.
Performance comparison of dual-ended readout depth-encoding PET detectors based on BGO and LYSO crystals.
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基于BGO和LYSO晶体的双端读出深度编码PET探测器的性能比较。
DOI：
10.1088/1361-6560/abc365
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发表时间：
2020-11-27
影响因子：
3.5
通讯作者：
Cherry SR
中科院分区：
文献类型：
--
作者：
Du J;Ariño-Estrada G;Bai X;Cherry SR
首次测量了基于锗酸铋 (BGO) 与硅光电倍增管 (SiPM) 阵列耦合的双端读出深度编码正电子发射断层扫描 (PET) 探测器的性能，并与使用相同读出装置的基于镥钇氧正硅酸盐 (LYSO) 的探测器进行了比较。 BGO 和 LYSO 晶体阵列的晶体间距均为 2.2 mm，并使用一对一耦合配置耦合到匹配间距为 2.2 mm 的 8 × 8 SiPM 阵列。使用了三种带有东丽反射镜的晶体：抛光 LYSO、抛光 BGO 和未抛光 BGO，以及两种不同的晶体厚度：20 毫米和 30 毫米。 BGO 阵列中的所有晶体元素在洪水直方图中都清晰可见。对于选定的晶体厚度，使用 LYSO 阵列可以获得更好的泛光直方图；对于选定的晶体类型，使用 20 mm 厚的晶体阵列可以获得更好的泛光直方图。 20 mm 抛光 LYSO、抛光 BGO 和未抛光 BGO 晶体在最佳 SiPM 偏置电压下的平均晶体级能量分辨率和时间分辨率分别为 18.6 ± 1.3% 和 1.19 ± 0.20 ns、17.8 ± 0.8% 和 4.43 ± 0.47 ns、以及 18.0 ± 1.0% 和 4.68 ± 1.0 ns，分别。 20 mm 抛光 LYSO 阵列的交互深度 (DOI) 分辨率为 2.31 ± 0.17 mm，20 mm 未抛光 BGO 阵列的交互深度 (DOI) 分辨率为 3.53 ± 0.25 mm。然而，带有东丽反射器的抛光 BGO 阵列不提供 DOI 信息。我们的主要结论是，双端读出深度编码 20 mm 厚的未抛光 BGO 探测器是视野小、定时性能要求低的低活性 PET 系统的良好候选者，例如临床前或紧凑型器官专用 PET 系统，与 LYSO 相比，其优点是无背景辐射且成本显着降低。
The performance of dual-ended readout depth-encoding positron emission tomography (PET) detectors based on bismuth germanate (BGO) coupled to silicon photomultipliers (SiPM) arrays was measured for the first time and compared to lutetium-yttrium oxyorthosilicate (LYSO)-based detectors using the same readout. The BGO and LYSO crystal arrays all had a crystal pitch of 2.2 mm and were coupled to 8 × 8 SiPM arrays with a matching pitch of 2.2 mm, using a one-to-one coupling configuration. Three types of crystals with Toray reflector were used: polished LYSO, polished BGO, and unpolished BGO, and for two different crystal thicknesses of 20 mm and 30 mm. All the crystal elements in the BGO arrays were clearly resolved in the flood histogram. Better flood histograms were obtained using the LYSO arrays for a selected crystal thickness, and better flood histograms were obtained using the 20 mm thick crystal arrays for a selected crystal type. The average crystal level energy resolution and timing resolution for 20 mm polished LYSO, polished BGO and unpolished BGO crystals at their optimal SiPM bias voltage were 18.6 ± 1.3% and 1.19 ± 0.20 ns, 17.8 ± 0.8% and 4.43 ± 0.47 ns, and 18.0 ± 1.0% and 4.68 ± 1.0 ns, respectively. Depth-of-interaction (DOI) resolution of the 20 mm polished LYSO array was 2.31 ± 0.17 mm and for the 20 mm unpolished BGO array was 3.53 ± 0.25 mm. However, polished BGO arrays with Toray reflector did not provide DOI information. Our key conclusion is that dual-ended readout depth-encoding 20 mm thick unpolished BGO detectors are good candidates for low-activity PET systems with small field-of-view and low timing performance requirements, such as preclinical or compact organ-dedicated PET systems, with the advantage over LYSO of having no background radiation and significantly lower cost.
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影响因子：
3.5
作者：
Du J;Bai X;Gola A;Acerbi F;Ferri A;Piemonte C;Yang Y;Cherry SR
通讯作者：
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