Performance of a high-resolution depth-encoding PET detector module using linearly-graded SiPM arrays.
Performance of a high-resolution depth-encoding PET detector module using linearly-graded SiPM arrays.
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DOI：
10.1088/1361-6560/aaa707
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发表时间：
2018-02-05
影响因子：
3.5
通讯作者：
Cherry SR
中科院分区：
文献类型：
--
作者：
Du J;Bai X;Gola A;Acerbi F;Ferri A;Piemonte C;Yang Y;Cherry SR
本研究的目标是利用位置敏感硅光电倍增管 (SiPM) 优异的空间分辨率特性，开发高分辨率交互深度 (DOI) 编码正电子发射断层扫描 (PET) 探测器模块。该探测器由 30 × 30 的 0.445 × 0.445 × 20 mm3 抛光 LYSO 晶体阵列组成，两端耦合到两个 15.5 × 15.5 mm2 线性渐变 SiPM (LG-SiPM) 阵列。洪水直方图显示 LYSO 阵列中的所有晶体都可以被解析。在 -10 °C 温度和 35.0 V 偏置电压下，能量分辨率、符合时间分辨率和 DOI 分辨率分别为 21.8 ± 5.8 %、1.23 ± 0.10 ns 和 3.8 ± 1.2 mm。对于高达每秒 130,000 次计数的事件率，性能并未显着下降。该探测器代表了小口径 PET 扫描仪设计的一个有吸引力的选择，同时强调高空间分辨率和高检测效率，这在例如使用神经受体配体对啮齿动物大脑进行临床前成像时很重要。
The goal of this study was to exploit the excellent spatial resolution characteristics of a position-sensitive silicon photomultiplier (SiPM) and develop a high-resolution depth-of-interaction (DOI) encoding positron emission tomography (PET) detector module. The detector consists of a 30 × 30 array of 0.445 × 0.445 × 20 mm3 polished LYSO crystals coupled to two 15.5 × 15.5 mm2 linearly-graded SiPM (LG-SiPM) arrays at both ends. The flood histograms show that all the crystals in the LYSO array can be resolved. The energy resolution, the coincidence timing resolution and the DOI resolution were 21.8 ± 5.8 %, 1.23 ± 0.10 ns and 3.8 ± 1.2 mm, respectively, at a temperature of −10 °C and a bias voltage of 35.0 V. The performance did not degrade significantly for event rates of up to 130,000 counts per second. This detector represents an attractive option for small-bore PET scanner designs that simultaneously emphasize high spatial resolution and high detection efficiency, important, for example, in preclinical imaging of the rodent brain with neuroreceptor ligands.
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影响因子：
1.8
作者：
Li H;Wang C;Baghaei H;Zhang Y;Ramirez R;Liu S;An S;Wong WH
通讯作者：
Wong WH
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Cherry SR
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作者：
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通讯作者：
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