Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.
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DOI：
10.3389/fnmol.2016.00099
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发表时间：
2016
影响因子：
4.8
通讯作者：
Kobow K
中科院分区：
文献类型：
--
作者：
Kiese K;Jablonski J;Boison D;Kobow K
在所有的生命系统中，无处不在的代谢中介和核苷腺苷是一个“主调节器”。在基线条件下，腺苷激酶(ADK)是腺苷代谢清除的主要酶。通过调节腺苷的可获得性，ADK是复杂的体内平衡和代谢网络的关键上游调节因子。不足为奇的是，ADK功能障碍与多种病理有关，包括糖尿病、癫痫和癌症。ADK蛋白存在于核ADK-L和胞浆ADK-S两种亚型中，它们在脑发育过程中和脑损伤后都会受到动态表达的影响，但其基因表达的变化以及指导ADK细胞类型和亚型特异性表达的调控机制尚未被研究过。在这里，我们分析了可能影响ADK表达的潜在基因调控机制，包括DNA启动子甲基化、组蛋白修饰和转录因子结合。我们的数据表明，转录因子SP1与ADK启动子的结合影响ADK表达的调节。
The ubiquitous metabolic intermediary and nucleoside adenosine is a “master regulator” in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex homeostatic and metabolic networks. Not surprisingly, ADK dysfunction is involved in several pathologies, including diabetes, epilepsy, and cancer. ADK protein exists in the two isoforms nuclear ADK-L, and cytoplasmic ADK-S, which are subject to dynamic expression changes during brain development and in response to brain injury; however, gene expression changes of the Adk gene as well as regulatory mechanisms that direct the cell-type and isoform specific expression of ADK have never been investigated. Here we analyzed potential gene regulatory mechanisms that may influence Adk expression including DNA promoter methylation, histone modifications and transcription factor binding. Our data suggest binding of transcription factor SP1 to the Adk promoter influences the regulation of Adk expression.
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影响因子：
1.3
作者：
Giglioni, S.;Leoncini, R.;Vannoni, D.
通讯作者：
Vannoni, D.
影响因子：
4.8
作者：
MacLaughlin, M;MartinezSalgado, C;LopezNovoa, JM
通讯作者：
LopezNovoa, JM
影响因子：
64.5
作者：
Guenther, Matthew G.;Levine, Stuart S.;Young, Richard A.
通讯作者：
Young, Richard A.
影响因子：
5.6
作者：
Boison, D;Huber, A;Möhler, H
通讯作者：
Möhler, H
影响因子：
4.7
作者：
Boison, Detlev;Singer, Philipp;Shen, Hai-Ying;Feldon, Joram;Yee, Benjamin K.
通讯作者：
Yee, Benjamin K.