Excision of beta-L- and beta-D-nucleotide analogs from DNA by p53 protein.
Excision of beta-L- and beta-D-nucleotide analogs from DNA by p53 protein.
复制标题
p53 蛋白从 DNA 中切除 β-L- 和 β-D-核苷酸类似物。
DOI：
10.1080/15257770008033019
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Cheng,YC
中科院分区：
文献类型：
--
作者：
Kukhanova,M;Liu,TW;Pelicano,H;Cheng,YC
The tumor suppressor p53protein plays a critical role in the cell-cycle progression. The role of the 3′-to-5′ exonuclease activity of p53 protein in the DNA repair process remains elusive. Using anin vitroexonuclease assay and defined oligonucleotides terminated with β-D- and β-L-nucleoside analogs at the 3′-terminus, we studied the ability of p53 protein to excise β-L- and β-D-nucleoside analogs which have anticancer or antiviral potential. p53 protein removes β-D-nucleoside analogs more efficiently compared to that of β-L-nucleoside analogs. The affinity of p53 protein for an β-L-nucleotide terminated primer was 5 fold lower compared to non-modified primer. The hypothesis on an important role of the 3′-to-5′ exonuclease activity of p53 protein in the action of nucleoside analogs was proposed.
1,8-二硝基芘诱导的大鼠纤维肉瘤中c-Ki-ras基因的结构
影响因子：
5.3
作者：
T. Tahira;K. Hayashi;M. Ochiai;N. Tsuchida;M. Nagao;T. Sugimura
通讯作者：
T. Sugimura