Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene

Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene
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1,8-二硝基芘诱导的大鼠纤维肉瘤中c-Ki-ras基因的结构

DOI:
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发表时间:
1986
影响因子:
5.3
通讯作者:
T. Sugimura
T. Sugimura
中科院分区:
生物学2区
文献类型:
--
作者:
T. Tahira;K. Hayashi;M. Ochiai;N. Tsuchida;M. Nagao;T. Sugimura

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限制酶图谱是由 1,8-二硝基芘诱导的大鼠纤维肉瘤 (1,8-DNP2) 的激活 c-Ki-ras 的外显子 1 和 2 周围区域制成的。核苷酸序列分析表明,激活的c-Ki-ras 在密码子12 中显示出G----T 颠换,因此在正常大鼠c-Ki-ras 中编码半胱氨酸而不是甘氨酸。
Restriction enzyme maps were made of the region around exons 1 and 2 of activated c-Ki-ras of a fibrosarcoma (1,8-DNP2) induced in a rat by 1,8-dinitropyrene. Nucleotide sequence analysis revealed that activated c-Ki-ras shows a G----T transversion in codon 12 and consequently encodes cysteine instead of glycine in normal rat c-Ki-ras.
DOI: 10.1126/science.6287573
发表时间: 1982-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
TSUCHIDA, N;RYDER, T;OHTSUBO, E
通讯作者: OHTSUBO, E