The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism.
The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism.
复制标题
DOI：
10.3390/ijms22179548
复制
发表时间：
2021-09-02
影响因子：
5.6
通讯作者：
Ruoppolo M
中科院分区：
文献类型：
--
作者：
Caterino M;Costanzo M;Fedele R;Cevenini A;Gelzo M;Di Minno A;Andolfo I;Capasso M;Russo R;Annunziata A;Calabrese C;Fiorentino G;D'Abbraccio M;Dell'Isola C;Fusco FM;Parrella R;Fabbrocini G;Gentile I;Castaldo G;Ruoppolo M
2019冠状病毒病是一种全球威胁，自2019年底以来一直在传播，在世界大流行的背景下造成严重的临床后遗症和死亡。高致病性和传染性的SARS-CoV-2冠状病毒的感染已被证明会对代谢产生全身影响。然而，参与COVID-19病理生理和进展的代谢途径仍不清楚。在这里，我们对52名住院的COVID-19患者进行了基于质谱的靶向代谢组学分析，根据疾病严重程度分为轻度、中度和重度。我们的分析定义了COVID-19的一个明确特征，包括在所有形式的疾病中血清乳酸水平升高。通路分析显示能量产生和氨基酸代谢失调。在全球范围内，COVID-19患者血清代谢组的变化可能反映了SARS-CoV-2引起的更复杂的全身扰动，可能影响肝脏的碳和氮代谢。
COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in the context of a world pandemic. The infection of the highly pathogenetic and infectious SARS-CoV-2 coronavirus has been proven to exert systemic effects impacting the metabolism. Yet, the metabolic pathways involved in the pathophysiology and progression of COVID-19 are still unclear. Here, we present the results of a mass spectrometry-based targeted metabolomic analysis on a cohort of 52 hospitalized COVID-19 patients, classified according to disease severity as mild, moderate, and severe. Our analysis defines a clear signature of COVID-19 that includes increased serum levels of lactic acid in all the forms of the disease. Pathway analysis revealed dysregulation of energy production and amino acid metabolism. Globally, the variations found in the serum metabolome of COVID-19 patients may reflect a more complex systemic perturbation induced by SARS-CoV-2, possibly affecting carbon and nitrogen liver metabolism.
登录
查看更多内容
影响因子：
1.2
作者：
Costanzo M;Caterino M;Cevenini A;Jung V;Chhuon C;Lipecka J;Fedele R;Guerrera IC;Ruoppolo M
通讯作者：
Ruoppolo M
影响因子：
5.6
作者：
Costanzo, Michele;Caterino, Marianna;Ruoppolo, Margherita
通讯作者：
Ruoppolo, Margherita
影响因子：
5.2
作者：
Han, Yi;Zhang, Haidong;Gu, Guorong
通讯作者：
Gu, Guorong
影响因子：
5.6
作者：
Costanzo M;Cevenini A;Marchese E;Imperlini E;Raia M;Del Vecchio L;Caterino M;Ruoppolo M
通讯作者：
Ruoppolo M
影响因子：
82.9
作者：
Del Valle DM;Kim-Schulze S;Huang HH;Beckmann ND;Nirenberg S;Wang B;Lavin Y;Swartz TH;Madduri D;Stock A;Marron TU;Xie H;Patel M;Tuballes K;Van Oekelen O;Rahman A;Kovatch P;Aberg JA;Schadt E;Jagannath S;Mazumdar M;Charney AW;Firpo-Betancourt A;Mendu DR;Jhang J;Reich D;Sigel K;Cordon-Cardo C;Feldmann M;Parekh S;Merad M;Gnjatic S
通讯作者：
Gnjatic S