Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.
Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.
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原神经基因活性的空间调节：无毛纲的自身和交叉激活被大毛纲外拮抗。
DOI：
10.1101/gad.6.12b.2592
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发表时间：
1992
影响因子：
10.5
通讯作者：
J. Posakony
中科院分区：
文献类型：
--
作者：
M. Doren;Patricia A. Powell;Dahna Pasternak;Andrew Singson;J. Posakony
Achaete (ac) 和 scute (sc) 的空间受限活动被认为定义了果蝇成虫盘中潜在感觉器官前体细胞的原神经簇。这些基因编码基本螺旋-环-螺旋（bHLH）类的转录调节因子。我们发现，ac 蛋白的直接正向转录自动调节和 sc 的交叉调节对于 ac 启动子在原神经簇模式中的高水平表达至关重要，并且自动激活对于 ac 基因的刚毛促进功能很重要。这些自动和交叉调节活性被大毛纲 (emc) 基因编码的抑制性 HLH 蛋白以剂量依赖性方式拮抗。我们发现 emc 在翼成虫盘中的表达模式与原神经簇的模式强烈互补。我们的结果表明，电磁兼容在确定刷毛形成潜力的区域方面发挥着重要的早期作用。
The spatially restricted activities of achaete (ac) and scute (sc) are thought to define proneural clusters of potential sensory organ precursor cells in the imaginal discs of Drosophila. These genes encode transcriptional regulators of the basic helix-loop-helix (bHLH) class. We have found that direct, positive transcriptional autoregulation by the ac protein and cross-regulation by sc are essential for high-level expression of the ac promoter in the proneural cluster pattern and that autoactivation is important for the bristle-promoting function of the ac gene. These auto- and cross-regulatory activities are antagonized in a dose-dependent manner by the inhibitory HLH protein encoded by the extramacrochaetae (emc) gene. We have found that emc is expressed in the wing imaginal disc in a pattern strongly complementary to that of the proneural clusters. Our results indicate that emc plays an essential early role in defining territories of bristle-forming potential.
影响因子：
10.5
作者：
S. Romani;S. Campuzano;E. Macagno;J. Modolell
通讯作者：
S. Romani;S. Campuzano;E. Macagno;J. Modolell
影响因子：
10.5
作者：
JIANG, J;KOSMAN, D;LEVINE, M
通讯作者：
LEVINE, M