Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Is hypoimmunogenic stem cell therapy safe in times of pandemics?
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DOI：
10.1016/j.stemcr.2022.02.014
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发表时间：
2022-04-12
影响因子：
5.9
通讯作者：
Drukker, Micha
中科院分区：
文献类型：
--
作者：
Matheus, Friederike;Raveh, Tal;Oro, Anthony E.;Wernig, Marius;Drukker, Micha
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies. In this perspective, Matheus and colleagues discuss potential risks and limitations of “universal” grafts from hypoimmunogenic pluripotent stem cells. They raise concerns regarding the possibility of infection, e.g., by SARS-CoV-2, due to immunologically cloaked transplants, and consider the applicability of hypoimmunogenic cells in therapies necessitating functional MHC presentation, including hematopoietic stem cell, immunological, and cutaneous disorders.
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DOI：
10.1073/pnas.1714478115
发表时间：
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