Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.
Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.
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DOI：
10.1016/j.humimm.2008.09.009
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发表时间：
2008-12
期刊：
影响因子：
2.7
通讯作者：
Ennis, Francis A.
中科院分区：
文献类型：
--
作者：
Terajima, Masanori;Orphin, Laura;Leporati, Anita M.;Pazoles, Pamela;Cruz, John;Rothman, Alan L.;Ennis, Francis A.
牛痘病毒（VACV）免疫导致了对天花的长期保护和成功的全球根除疾病。VACV引起强烈的细胞和体液免疫反应。虽然中和抗体对保护至关重要，但细胞免疫似乎对人类感染后的恢复更为重要。我们分析了56名初次接种疫苗的供者中73个先前鉴定的由HLA-A1、A2、A3、A24、B7或B44等位基因或属于这些超型之一的等位基因限制的VACV人CD8+ T细胞表位的免疫优势等级。除了对HLA- a24超型限制性表位的反应外，在具有相同HLA等位基因或超型的供体中没有一致的表位免疫优势模式，这与小鼠研究形成鲜明对比。然而，我们确定了12个表位，这些表位被具有相同HLA等位基因的≥20%的供者识别；其中6个至少在一个个体中贡献了总vacv特异性T细胞应答的20%以上。vacv特异性CD8+ T细胞应答针对的是一组“相对优势”的表位，在人类中没有很强的免疫优势等级，这可能有利于人类防止T细胞逃逸突变体的出现。
Immunization with vaccinia virus (VACV) resulted in long-lasting protection against smallpox and successful global eradication of the disease. VACV elicits strong cellular as well as humoral immune responses. Although neutralizing antibody is essential for protection, cellular immunity seems to be more important for recovery from infection in humans. We analyzed the immunodominance hierarchy of 73 previously identified VACV human CD8+ T cell epitopes restricted by HLA-A1, A2, A3, A24, B7 or B44 alleles or the alleles belonging to one of these supertypes in 56 donors after primary VACV immunization. Except for the responses to HLA-A24 supertype-restricted epitopes, there were no consistent patterns of epitope immunodominance among donors sharing the same HLA alleles or supertypes, which is in sharp contrast with the mouse studies. We, however, identified 12 epitopes that were recognized by ≥20% of donors sharing the same HLA allele; six of these contributed ≥20% of the total VACV-specific T cell response in at least one individual. VACV-specific CD8+ T cell responses targeted a group of epitopes, “relatively dominant” epitopes, without a strong immunodominance hierarchy in humans, which may be advantageous to humans to prevent the emergence of T cell escape mutants.
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影响因子：
5.4
作者：
Benhnia, Mohammed Rafii-El-Idrissi;McCausland, Megan M.;Crotty, Shane
通讯作者：
Crotty, Shane
影响因子：
11.5
作者：
Di Nicola, M;Carlo-Stella, C;Anichini, A
通讯作者：
Anichini, A
影响因子：
5.9
作者：
FREED, ER;DUMA, RJ;ESCOBAR, MR
通讯作者：
ESCOBAR, MR
影响因子：
4.6
作者：
Ostrout, N. D.;McHugh, M. M.;Kazura, J. W.
通讯作者：
Kazura, J. W.
DOI：
10.1073/pnas.0711573105
发表时间：
2008-02-12
影响因子：
11.1
作者：
Assarsson, Erika;Greenbaum, Jason A.;Sette, Alessandro
通讯作者：
Sette, Alessandro