Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation.
Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation.
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牛磺酸基化合物作为二氧化硅诱导的过氧化反应中羟基自由基清除剂的功效。
DOI：
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发表时间：
1997
影响因子：
0.8
通讯作者：
V. Castranova
中科院分区：
文献类型：
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作者：
X. Shi;D. Flynn;D. Porter;S. Leonard;V. Vallyathan;V. Castranova
虽然人们普遍认为，牛磺酸可能发挥重要作用，保护细胞免受毒性损伤，作为一种抗氧化剂，但缺乏证据支持这一假设。本文用电子自旋共振（ESR）方法研究了牛磺酸和亚牛磺酸与羟基自由基（.OH）的反应。以芬顿反应（Fe（II）+H2 O2-->Fe（III）+ .OH + OH-）和Cr（V）介导的类芬顿反应（Cr（V）+H2 O2-->Cr（VI）+ .OH + OH-）作为.OH自由基的来源。结果表明，亚牛磺酸能有效清除.OH自由基，反应速率常数k = 1.6 × 10（10）M-1 s-1，牛磺酸不能。这与其他有效的.OH自由基清除剂相当。以亚油酸为模型脂质，研究了牛磺酸和亚牛磺酸对二氧化硅诱导的脂质过氧化作用的影响。亚牛磺酸，而不是牛磺酸，引起了显着抑制二氧化硅诱导的脂质过氧化反应。结果表明，亚牛磺酸是一种优良的抗氧化剂，似乎有可能成为一种治疗剂，对二氧化硅诱导的肺损伤。
While it is widely believed that taurine may play an important role in protecting cells against toxic injury by functioning as an antioxidant, there is a lack of evidence to support this hypothesis. In this study, electron spin resonance (ESR) was used to investigate the reaction of taurine and hypotaurine with hydroxyl radicals (.OH). The Fenton reaction (Fe(II) + H2O2-->Fe(III) + .OH + OH-) and the Cr(V)-mediated Fenton-like reaction (Cr(V) + H2O2-->Cr(VI) + .OH + OH-) were used as sources of .OH radicals. The results show that hypotaurine but not taurine effectively scavenges .OH radicals with a reaction rate constant of k = 1.6 x 10(10) M-1s-1. That is comparable with other efficient .OH radical scavengers. The effect of taurine and hypotaurine on silica-induced lipid peroxidation was evaluated using linoleic acid as a model lipid. Hypotaurine, but not taurine, caused a significant inhibition of silica-induced lipid peroxidation. The results show that hypotaurine is an excellent antioxidant and appears to have the potential for being a therapeutic agent against silica-induced lung injury.
二氧化硅和一些硅酸盐。
DOI：
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发表时间：
1987
期刊：
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans
影响因子：
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作者：
通讯作者：
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牛磺酸在中性粒细胞对红细胞的体外氧化毒性中作用的证据。
DOI：
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发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Thomas,EL;Grisham,MB;Melton,DF;Jefferson,MM
通讯作者：
Jefferson,MM
DOI：
10.3109/10715769309056s79
发表时间：
1993-01-01
期刊：
FREE RADICAL RESEARCH COMMUNICATIONS
影响因子：
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作者：
BUETTNER, GR
通讯作者：
BUETTNER, GR