Impact of COVID-19 on the thyroid gland: an update.
Impact of COVID-19 on the thyroid gland: an update.
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DOI：
10.1007/s11154-020-09615-z
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发表时间：
2021-12
影响因子：
8.2
通讯作者：
Trimboli P
中科院分区：
文献类型：
--
作者：
Scappaticcio L;Pitoia F;Esposito K;Piccardo A;Trimboli P
2019冠状病毒病（COVID-19）是新千年的大流行。COVID-19可引起肺部和全身炎症，可能导致多器官功能障碍。自2020年3月以来，关于COVID-19与甲状腺之间关系的数据不断涌现，并迅速增加。众所周知，甲状腺和病毒感染及其相关的炎症免疫反应参与了复杂的相互作用。SARS-CoV-2利用ACE2结合跨膜蛋白酶丝氨酸2 （TMPRSS2）作为感染宿主细胞的关键分子复合体。有趣的是，ACE2和TMPRSS2在甲状腺中的表达水平很高，比在肺中的表达水平高。我们的文献检索提供了更多的证据，证明甲状腺和整个下丘脑-垂体-甲状腺（HPT）轴可能是SARS-CoV-2损伤的相关靶点。具体而言，与covid -19相关的甲状腺疾病包括甲状腺毒症、甲状腺功能减退以及非甲状腺疾病综合征。此外，我们注意到甲状腺癌的治疗计划正朝着远程会诊更多、诊断和治疗程序更少的方向发生重大变化。考虑到全球对COVID-19的研究速度之快，目前的审查包括的发现可能很快就会因该主题的新成果而改变。
Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. SARS-CoV-2 uses ACE2 combined with the transmembrane protease serine 2 (TMPRSS2) as the key molecular complex to infect the host cells. Interestingly, ACE2 and TMPRSS2 expression levels are high in the thyroid gland and more than in the lungs. Our literature search provided greater evidence that the thyroid gland and the entire hypothalamic–pituitary–thyroid (HPT) axis could be relevant targets of damage by SARS-CoV-2. Specifically, COVID-19-related thyroid disorders include thyrotoxicosis, hypothyroidism, as well as nonthyroidal illness syndrome. Moreover, we noticed that treatment plans for thyroid cancer are considerably changing in the direction of more teleconsultations and less diagnostic and therapeutical procedures. The current review includes findings that could be changed soon by new results on the topic, considering the rapidity of worldwide research on COVID-19.
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10.15557/pimr.2020.0003
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影响因子：
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