Associations between remnant lipoprotein cholesterol and central systolic blood pressure in a Chinese community-based population: a cross-sectional study.
Associations between remnant lipoprotein cholesterol and central systolic blood pressure in a Chinese community-based population: a cross-sectional study.
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中国社区人群中残留的脂蛋白胆固醇与中央收缩压之间的关联：一项横断面研究。
DOI：
10.1186/s12944-021-01490-0
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发表时间：
2021-06-26
影响因子：
4.5
通讯作者：
Huo Y
中科院分区：
文献类型：
--
作者：
Li K;Fan F;Zheng B;Jia J;Liu B;Liu J;Chen C;Zhou J;Zhang Y;Huo Y
据报道，血脂与外周血压或脉搏波速度有关。然而，没有研究调查血脂参数，特别是残余脂蛋白胆固醇（RLP-C）和中心收缩压（cSBP）之间的关联。本研究使用了中国北京社区队列的基线数据。排除了接受过降压或降脂药物治疗的受试者。RLP-C等于总胆固醇（TC）减去低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的总和。使用Omron HEM-9000 AI装置测量无创cSBP。使用多变量回归模型评估血脂谱与无创cSBP之间的相关性。纳入的5173名参与者年龄为55.0 ± 8.5岁; 35.7%（1845）的参与者为男性。cSBP升高与TC、LDL-C、非高密度脂蛋白胆固醇（非HDL-C）、甘油三酯（TG）和RLP-C升高显著相关，但与HDL-C降低显著相关，即使在调整可能的协变量后也是如此。当同时将单个对的RLP-C和其他血脂参数输入多变量回归模型时，即使在调整其他血脂后，RLP-C仍与cSBP显著相关。与RLP-C水平在第一四分位数（Q1）的参与者相比，Q4中RLP-C水平的参与者的cSBP增加至4.57（95%置信区间[CI]：3.08-6.06）校正LDL-C后mmHg，4.50（95%CI：2.98-6.02）校正TC后mmHg，3.91校正TG后为1.92-5.89 mmHg，校正HDL-C后为5.15 mmHg（95%CI：3.67-6.63）mmHg，校正非HDL-C后为4.10 mmHg（95%CI：2.36-5.84）。在中国人群中，血RLP-C水平升高与cSBP升高显著相关，与其他脂质无关，这表明其在个体心血管风险评估中的重要性。
The lipid profile is reportedly related to peripheral blood pressure or pulse wave velocity. However, no studies have investigated the associations between lipid parameters, especially remnant lipoprotein cholesterol (RLP-C), and central systolic blood pressure (cSBP). This study used baseline data of a community-based cohort in Beijing, China. Participants who had been treated with anti-hypertensive or lipid-lowering agents were excluded. RLP-C is equal to total cholesterol (TC) minus the sum of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). An Omron HEM-9000AI device was used to measure non-invasive cSBP. The associations between blood lipid profile and non-invasive cSBP were evaluated using multivariable regression models. The 5173 included participants were 55.0 ± 8.5 years old; 35.7% (1845) of participants were men. Increased cSBP was significantly associated with increased TC, LDL-C, non-high-density lipoprotein cholesterol (non-HDL-C), triglyceride (TG), and RLP-C but with decreased HDL-C, even after adjusting for possible covariates. When simultaneously entering individual pairs of RLP-C and other blood lipid parameters into the multivariable regression model, RLP-C remained significantly associated with cSBP, even after adjusting for other lipids. Compared with participants who had RLP-C levels in the first quartile (Q1), cSBP for those with RLP-C in Q4 was increased to 4.57 (95% confidence interval [CI]: 3.08–6.06) mmHg after adjusting for LDL-C, 4.50 (95%CI: 2.98–6.02) mmHg after adjusting for TC, 3.91 (95%CI: 1.92–5.89) mmHg after adjusting for TG, 5.15 (95%CI: 3.67–6.63) mmHg after adjusting for HDL-C, and 4.10 (95%CI: 2.36–5.84) mmHg after adjusting for non-HDL-C. Increased blood RLP-C level was significantly associated with higher cSBP in a Chinese population, independently of other lipids, which indicates its importance in individual cardiovascular risk assessment.
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影响因子：
39.3
作者：
Chapman MJ;Ginsberg HN;Amarenco P;Andreotti F;Borén J;Catapano AL;Descamps OS;Fisher E;Kovanen PT;Kuivenhoven JA;Lesnik P;Masana L;Nordestgaard BG;Ray KK;Reiner Z;Taskinen MR;Tokgözoglu L;Tybjærg-Hansen A;Watts GF;European Atherosclerosis Society Consensus Panel
通讯作者：
European Atherosclerosis Society Consensus Panel
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2.3
作者：
Fan F;Jia J;Li J;Huo Y;Zhang Y
通讯作者：
Zhang Y
影响因子：
39.3
作者：
Boren, Jan;Chapman, M. John;Ginsberg, Henry N.
通讯作者：
Ginsberg, Henry N.
影响因子：
8.3
作者：
Kollias, Anastasios;Lagou, Styliani;Stergiou, George S.
通讯作者：
Stergiou, George S.
影响因子：
24
作者：
Balling, Mie;Afzal, Shoaib;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.