Development of a geometry-based respiratory motion-simulating patient model for radiation treatment dosimetry.
Development of a geometry-based respiratory motion-simulating patient model for radiation treatment dosimetry.
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开发用于放射治疗剂量测定的基于几何的呼吸运动模拟患者模型。
DOI：
10.1120/jacmp.v9i1.2700
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发表时间：
2008-01-21
影响因子：
2.1
通讯作者：
Fuss, Martin
中科院分区：
文献类型：
--
作者：
Zhang, Juying;Xu, X. George;Shi, Chengyu;Fuss, Martin
在放射治疗递送期间由呼吸引起的时间和空间解剖变化可导致处方和实际辐射剂量之间的差异。本文记录了一项研究，旨在构建一个模拟呼吸运动的四维（4D）解剖学和剂量学模型，用于研究各种放射治疗计划和输送策略对器官运动的剂量学影响。非均匀有理B-样条（NURBS）方法已经被用于重建三维（3D）VIP-Man（“可视摄影人”）模型，该模型可以通过使用时间相关方程来操纵表面控制点来反映呼吸期间器官的变形。然后使用EGS 4（电子伽马簇射，版本4）蒙特卡罗代码将4D模型应用于剂量模拟。我们模拟了两种放射治疗输送场景：门控治疗和4D图像引导治疗。对于每种输送方案，我们制定了一个适形计划和一个调强放射治疗计划。模拟左肺病变，研究呼吸运动对辐射剂量分布的影响。基于靶区剂量-体积直方图，论证了精确门控对改善剂量分布的重要性。结果还表明，在4D图像引导治疗输送期间，监测患者的呼吸模式至关重要。本研究证明了使用“标准”运动模拟患者模型进行4D治疗计划和运动管理的潜力。PACS编号：87.53.Bn、87.53.Kn、87.53.Tf、87.53.Wz、87.57.Gg、89.80.+ H
Temporal and spatial anatomic changes caused by respiration during radiation treatment delivery can lead to discrepancies between prescribed and actual radiation doses. The present paper documents a study to construct a respiratory‐motion‐simulating, four‐dimensional (4D) anatomic and dosimetry model for the study of the dosimetric effects of organ motion for various radiation treatment plans and delivery strategies. The non‐uniform rational B‐splines (NURBS) method has already been used to reconstruct a three‐dimensional (3D) VIP‐Man (“visible photographic man”) model that can reflect the deformation of organs during respiration by using time‐dependent equations to manipulate surface control points. The EGS4 (Electron Gamma Shower, version 4) Monte Carlo code is then used to apply the 4D model to dose simulation. We simulated two radiation therapy delivery scenarios: gating treatment and 4D image‐guided treatment. For each delivery scenario, we developed one conformal plan and one intensity‐modulated radiation therapy plan. A lesion in the left lung was modeled to investigate the effect of respiratory motion on radiation dose distributions. Based on target dose–volume histograms, the importance of using accurate gating to improve the dose distribution is demonstrated. The results also suggest that, during 4D image‐guided treatment delivery, monitoring of the patient's breathing pattern is critical. This study demonstrates the potential of using a “standard” motion‐simulating patient model for 4D treatment planning and motion management. PACS numbers: 87.53.Bn, 87.53.Kn, 87.53.Tf, 87.53.Wz, 87.57.Gg, 89.80.+h
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影响因子：
3.8
作者：
Ding, MS;Li, JS;Ma, CM
通讯作者：
Ma, CM
影响因子：
3.8
作者：
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Seuntjens, J
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2.2
作者：
Chao, TC;Bozkurt, A;Xu, XG
通讯作者：
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