Gut Microbial Changes and their Contribution to Post-Burn Pathology.
Gut Microbial Changes and their Contribution to Post-Burn Pathology.
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DOI：
10.1097/shk.0000000000001736
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发表时间：
2021-09-01
期刊：
影响因子：
--
通讯作者：
Choudhry MA
中科院分区：
文献类型：
--
作者：
Luck ME;Herrnreiter CJ;Choudhry MA
烧伤是一种常见的创伤性损伤，在世界范围内导致了很高的发病率和死亡率。烧伤的特点是炎症过程和许多器官系统和功能的改变。最近，人们发现胃肠道细菌微生物群是调节免疫反应和烧伤恢复的关键组成部分，也可能导致损伤后的严重有害后遗症，如败血症和多器官衰竭。微生物生态失调与多种疾病状态有关，然而，其在加剧急性创伤性损伤（如烧伤）中的作用尚不清楚。在本文中，我们回顾了记录烧伤后肠道微生物组变化的研究，评估了烧伤后发病机制的意义，以及进一步发现和研究的潜力。
Burn injuries are a common form of traumatic injury that leads to significant morbidity and mortality worldwide. Burn injuries are characterized by inflammatory processes and alterations in numerous organ systems and functions. Recently, it has become apparent that the gastrointestinal bacterial microbiome is a key component of regulating the immune response and recovery from burn and can also contribute to significant detrimental sequelae after injury, such as sepsis and multiple organ failure. Microbial dysbiosis has been linked to multiple disease states, however, its role in exacerbating acute traumatic injuries, such as burn, are poorly understood. In this article, we review studies that document changes in the intestinal microbiome after burn injury, assess the implications in post-burn pathogenesis, and the potential for further discovery and research.
影响因子：
4.3
作者：
Rice TC;Armocida SM;Kuethe JW;Midura EF;Jain A;Hildeman DA;Healy DP;Gulbins E;Caldwell CC
通讯作者：
Caldwell CC