Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.
Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.
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DOI：
10.1016/j.cellimm.2016.12.004
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发表时间：
2017-03
影响因子：
4.3
通讯作者：
Caldwell CC
中科院分区：
文献类型：
--
作者：
Rice TC;Armocida SM;Kuethe JW;Midura EF;Jain A;Hildeman DA;Healy DP;Gulbins E;Caldwell CC
烧伤后，患者容易发生机会性感染的一个关键因素是免疫抑制。丁酸盐水平对于维持功能性免疫系统很重要，并且这些水平在受伤后可能会发生变化。酸性鞘磷脂酶 (Asm) 脂质信号系统与 T 细胞活动有关，有证据表明其受到丁酸盐的影响。在这里，我们假设烧伤中丁酸盐水平的变化会介导 Asm 活性，从而介导 T 细胞稳态。我们证明烧伤会暂时降低丁酸盐水平。我们进一步确定，丁酸盐会增加 T 细胞 Asm 活性，而烧伤后会降低 T 细胞 Asm 活性。我们还观察到 Asm 缺陷、烧伤和微生物群耗尽的小鼠中 T 细胞数量减少。最后，我们证明丁酸以 Asm 依赖性方式减少 T 细胞死亡。这些数据表明，烧伤后恢复丁酸盐可能会改善烧伤患者中通过 Asm 调节观察到的 T 细胞损失。
Following burn injury, a key factor for patients susceptible to opportunistic infections is immune suppression. Butyrate levels are important in maintaining a functional immune system and these levels can be altered after injury. The acid sphingomyelinase (Asm) lipid signaling system has been implicated in a T cell actions with some evidence of being influenced by butyrate. Here, we hypothesized that burn-injury changes in butyrate levels would mediate Asm activity and, consequently, T cell homeostasis. We demonstrate that burn injury temporally decreases butyrate levels. We further determined that T cell Asm activity is increased by butyrate and decreased after burn injury. We additionally observed decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice. Finally, we demonstrate that butyrate reduced T cell death in an Asm-dependent manner. These data suggest that restoration of butyrate after burn injury may ameliorate the T cell lost observed in burn-injured patients by Asm regulation.
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DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.1073/pnas.1019378108
发表时间：
2011-03-29
影响因子：
11.1
作者：
Ichinohe, Takeshi;Pang, Iris K.;Iwasaki, Akiko
通讯作者：
Iwasaki, Akiko
DOI：
10.1073/pnas.1031788100
发表时间：
2003-05-27
影响因子：
11.1
作者：
Hotchkiss, RS;Chang, KC;Karl, IE
通讯作者：
Karl, IE
DOI：
10.2174/1874091x01004010053
发表时间：
2010-05-13
期刊：
The open biochemistry journal
影响因子：
--
作者：
Huda-Faujan N;Abdulamir AS;Fatimah AB;Anas OM;Shuhaimi M;Yazid AM;Loong YY
通讯作者：
Loong YY
影响因子：
15.9
作者：
García-Ruiz, C;Colell, A;Fernández-Checa, JC
通讯作者：
Fernández-Checa, JC