Association of the IL-6 Rs1800796 SNP with Concentration/dose Ratios of Tacrolimus and Donor Liver Function after Transplantation
Association of the IL-6 Rs1800796 SNP with Concentration/dose Ratios of Tacrolimus and Donor Liver Function after Transplantation
复制标题
IL-6 Rs1800796 SNP 与他克莫司浓度/剂量比和移植后供体肝功能的关联
DOI：
10.1080/08820139.2020.1793775
复制
发表时间：
2020-07
影响因子：
2.8
通讯作者：
王峰
中科院分区：
文献类型：
--
作者：
王峰
白细胞介素-6 （IL-6）是一种促炎细胞因子，在炎症、免疫反应和细胞生长调节等方面发挥着重要作用。在此，我们旨在评估IL-6单核苷酸多态性（SNP） rs1800796对中国肝移植患者他克莫司浓度/剂量（C/D）比和供体肝功能的潜在影响。本研究共纳入331例肝移植患者。分析有无IL-6 rs1800796 SNP的患者在不同时间点的C/D比值及ALT、AST、T-BIL、ALP、GGT水平。受体IL-6 rs1800796多态性与移植后2 ~ 6个月他克莫司C/D比值相关。供体rs1800796 SNP在移植后早期影响受者肝功能（ALT、AST、T-BIL、ALP和GGT数据）。由此可见，IL-6 rs1800796多态性与他克莫司C/D比值及移植后供肝功能相关。
ABSTRACT Interleukin-6 (IL-6) is a proinflammatory cytokine that plays a range of important roles such as in inflammation, immune response, and cell growth regulation. Here, we aimed to assess the potential influence of the IL-6 single nucleotide polymorphism (SNP) rs1800796 on the concentration/dose (C/D) ratios of tacrolimus and donor liver function in Chinese liver transplant patients. A total of 331 liver transplant patients were included in this study. The C/D ratios and the ALT, AST, T-BIL, ALP, and GGT levels were analyzed at different time points in patients with and without the IL-6 rs1800796 SNP. The IL-6 rs1800796 polymorphism in recipients was found to be correlated with the C/D ratios of tacrolimus at months 2 to month 6 after transplantation. Also, the rs1800796 SNP in donors was found to influence liver function (shown in the data of ALT, AST, T-BIL, ALP and GGT) in recipients at the early post-transplant stage after transplantation. In conclusion, the IL-6 rs1800796 polymorphism was associated with the C/D ratios of tacrolimus and post-transplant donor liver function.
登录
查看更多内容
DOI：
10.1038/nrgastro.2012.225
发表时间：
2013-02
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.1
作者：
O. Désy;S. Béland;P. Vallin;J. Riopel;É. Latulippe;N. Najafian;A. Chandraker;M. Agharazii;I. Batal;S. D. De Serres
通讯作者：
O. Désy;S. Béland;P. Vallin;J. Riopel;É. Latulippe;N. Najafian;A. Chandraker;M. Agharazii;I. Batal;S. D. De Serres
影响因子：
1.6
作者：
Jia Yao;Xiao-wen Feng;Xiaobo Yu;Haiyang Xie;Li-Xian Zhu;Zhe Yang;B. Wei;Shu-sen Zheng;Lin Zhou
通讯作者：
Jia Yao;Xiao-wen Feng;Xiaobo Yu;Haiyang Xie;Li-Xian Zhu;Zhe Yang;B. Wei;Shu-sen Zheng;Lin Zhou
影响因子：
2.1
作者：
Verleden, Stijn E.;Martens, An;Vos, Robin
通讯作者：
Vos, Robin
影响因子：
4.8
作者：
Terry, CF;Loukaci, V;Green, FR
通讯作者：
Green, FR