Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp.
Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp.
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DOI:
10.1016/j.yjmcc.2010.12.020
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发表时间:
2011-03
影响因子:
5
通讯作者:
Chen-Izu Y
中科院分区:
文献类型:
--
作者:
Banyasz T;Horvath B;Jian Z;Izu LT;Chen-Izu Y
The cardiac action potential (AP) is shaped by myriad ionic currents. In this study we develop an innovative AP-clamp Sequential Dissection technique to enable recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell. The ability to measure many currents in a single cell has revealed two hitherto unknown characteristics of the ionic currents in cardiac cells: coordination of currents within a cell and large variation of currents between cells. Hence, the AP-clamp Sequential Dissection method provides a unique and powerful tool for studying individual cell electrophysiology.
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影响因子:
20.1
作者:
Grantham, CJ;Cannell, MB
通讯作者:
Cannell, MB
影响因子:
4.5
作者:
DOERR, T;DENGER, R;TRAUTWEIN, W
通讯作者:
TRAUTWEIN, W
DOI:
10.1152/ajpheart.00562.2007
发表时间:
2007-10-01
影响因子:
4.8
作者:
Chen-Izu, Ye;Ward, Christopher W.;Wehrens, Xander H. T.
通讯作者:
Wehrens, Xander H. T.
影响因子:
4.5
作者:
DOERR, T;DENGER, R;TRAUTWEIN, W
通讯作者:
TRAUTWEIN, W
影响因子:
4.5
作者:
Linz, KW;Meyer, R
通讯作者:
Meyer, R