Affinity Sensors for the Diagnosis of COVID-19.
Affinity Sensors for the Diagnosis of COVID-19.
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DOI：
10.3390/mi12040390
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发表时间：
2021-04-02
期刊：
影响因子：
3.4
通讯作者：
Ramanavicius A
中科院分区：
文献类型：
--
作者：
Drobysh M;Ramanaviciene A;Viter R;Ramanavicius A
由严重急性呼吸综合征冠状病毒2号(SARS-CoV-2)引起的2019年新冠肺炎疫情于2020年3月被宣布为全球大流行。减少传播率，特别是通过跟踪感染者及其接触者，是防止感染传播的主要手段。因此，需要建立和实施适合新冠肺炎诊断的快速、可靠和灵敏的方法。使用亲和力传感器可以满足这些需求，这些传感器在应用的检测方法和产生分析信号的标记方面有所不同。目前，分析信号的产生主要采用核酸杂交、抗原抗体相互作用和活性氧(ROS)水平的变化等方法，可以通过电化学、光学、表面等离子体共振、场效应晶体管等方法和传感器对其进行精确测量。电化学生物传感器最符合生物分析过程加速和简化的大趋势。这些生物传感器主要基于抗原-抗体相互作用的确定，并且坚固、灵敏、准确，有时能够实现对分析物的无标记检测。除了生物传感器的规格外，我们还简要概述了常用的检测技术，并描述了SARS-CoV-2的结构、生命周期和免疫宿主反应，以及分析信号检测原理的一些更深层次的细节。
The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proclaimed a global pandemic in March 2020. Reducing the dissemination rate, in particular by tracking the infected people and their contacts, is the main instrument against infection spreading. Therefore, the creation and implementation of fast, reliable and responsive methods suitable for the diagnosis of COVID-19 are required. These needs can be fulfilled using affinity sensors, which differ in applied detection methods and markers that are generating analytical signals. Recently, nucleic acid hybridization, antigen-antibody interaction, and change of reactive oxygen species (ROS) level are mostly used for the generation of analytical signals, which can be accurately measured by electrochemical, optical, surface plasmon resonance, field-effect transistors, and some other methods and transducers. Electrochemical biosensors are the most consistent with the general trend towards, acceleration, and simplification of the bioanalytical process. These biosensors mostly are based on the determination of antigen-antibody interaction and are robust, sensitive, accurate, and sometimes enable label-free detection of an analyte. Along with the specification of biosensors, we also provide a brief overview of generally used testing techniques, and the description of the structure, life cycle and immune host response to SARS-CoV-2, and some deeper details of analytical signal detection principles.
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