Blood lead levels mediate the relationship between social adversity and child externalizing behavior.
Blood lead levels mediate the relationship between social adversity and child externalizing behavior.
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DOI：
10.1016/j.envres.2021.112396
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发表时间：
2022-03
影响因子：
8.3
通讯作者：
Chen, Aimin
中科院分区：
文献类型：
--
作者：
Liu, Jianghong;Portnoy, Jill;Raine, Adrian;Gladieux, Margaret;McGarry, Presley;Chen, Aimin
关键词：
社会逆境和儿童外化行为问题之间的关联是有据可查的。但对可能介导这种关系的生物学机制的研究要少得多。本研究检验了低血铅介导社会逆境与儿童外化行为问题之间关系的假设。在这项横断面研究中，参与者是来自美国费城的131名11-12岁（平均= 11.90）的儿童。采集静脉空腹血样并分析血铅水平。一个社会逆境指数计算的基础上，从父母和官方邻里数据的心理社会访谈得出的10个总指标，而儿童的行为结果（内化和外化行为）进行了评估，使用父母的报告和儿童的自我报告。平均血铅水平为2.20 μg/dL。较高的血铅水平和较高的社会逆境得分与较高水平的父母报告和儿童自我报告的外化行为有关。此外，血铅介导了社会逆境与儿童报告的外化行为之间的关系（间接效应：B = 0.03，95%CI：0.004，0.09），并部分介导了社会逆境与父母报告的外化行为之间的关系（间接效应：B = 0.03，95%CI：0.01，0.07）。据我们所知，这项研究是第一个提出血铅水平在外化行为问题和社会逆境之间的关系中发挥中介作用。研究结果对公共卫生和环境监管以及理解将社会不平等与健康结果联系起来的生物机制具有潜在的重要意义，特别是在低收入城市地区的青年中。
The association between social adversity and externalizing behavioral problems in children is well-documented. What is much less researched are biological mechanisms that may mediate such relationships. This study examines the hypothesis that low blood lead mediates the relationship between social adversity and child externalizing behavior problems. In this cross-sectional study, participants were 131 children aged 11–12 years (mean = 11.90) from the Philadelphia US. A venous fasting blood sample was taken and analyzed for blood lead level. A social adversity index was calculated based on 10 total indicators derived from a psychosocial interview of the parent and official neighborhood data, while child behavior outcomes (internalizing and externalizing behavior) were assessed using both parent-report and child self-report. The mean blood lead level was 2.20 μg/dL. Both relatively higher blood lead levels and higher social adversity scores were associated with higher levels of parent-reported and child self-reported externalizinsg behaviors. Additionally, blood lead mediated the relationship between social adversity and child-reported externalizing behavior (Indirect effect: B = 0.03, 95% CI: 0.004, 0.09) and partially mediated the relationship between social adversity and parent-reported externalizing behavior (Indirect Effect: B = 0.03, 95% CI: 0.01, 0.07). To our knowledge, this study is the first to suggest that blood lead levels play a mediating role in the relationship between externalizing behavior problems and social adversity. Findings have potentially important implications for public health and environmental regulation as well as understanding biological mechanisms that link social inequality with health outcomes, especially in youth from low-income, urban areas.
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