Time-resolved multi-channel optical system for assessment of brain oxygenation and perfusion by monitoring of diffuse reflectance and fluorescence
Time-resolved multi-channel optical system for assessment of brain oxygenation and perfusion by monitoring of diffuse reflectance and fluorescence
复制标题
时间分辨多通道光学系统，通过监测漫反射和荧光来评估脑氧合和灌注
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
A. Liebert
中科院分区：
文献类型：
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作者：
Daniel Milej;A. Gerega;M. Kacprzak;P. Sawosz;W. Weigl;R. Maniewski;A. Liebert
时间分辨近红外光谱是一种可用于组织氧合评估的光学技术。在过去的十年中，这种方法被广泛测试为一种潜在的临床工具，用于无创人脑功能监测和成像。在本论文中，我们显示了一种仪器的建设，它允许：（i）估计脑组织氧合的变化，使用双波长光谱法和（ii）脑灌注评估与使用单波长反射计或荧光测量结合ICG团跟踪。实现了一种基于测量光子飞行时间分布的统计矩的信号处理算法。该数据分析方法允许分离源自脑外和脑内组织隔室的信号。在本文中，我们提出了紧凑和易于重新配置的系统，可应用于不同类型的时间分辨实验：在687和832 nm的双波长测量，在760 nm（这是最大的ICG吸收光谱）的单波长反射率测量或荧光测量与激发在760 nm。详细的仪器结构和技术测试的结果。此外，在体内的测量结果获得的各种模式的操作系统。
Time-resolved near-infrared spectroscopy is an optical technique which can be applied in tissue oxygenation assessment. In the last decade this method is extensively tested as a potential clinical tool for noninvasive human brain function monitoring and imaging. In the present paper we show construction of an instrument which allows for: (i) estimation of changes in brain tissue oxygenation using two-wavelength spectroscopy approach and (ii) brain perfusion assessment with the use of single-wavelength reflectometry or fluorescence measurements combined with ICG-bolus tracking. A signal processing algorithm based on statistical moments of measured distributions of times of flight of photons is implemented. This data analysis method allows for separation of signals originating from extra- and intracerebral tissue compartments. In this paper we present compact and easily reconfigurable system which can be applied in different types of time-resolved experiments: two-wavelength measurements at 687 and 832 nm, single wavelength reflectance measurements at 760 nm (which is at maximum of ICG absorption spectrum) or fluorescence measurements with excitation at 760 nm. Details of the instrument construction and results of its technical tests are shown. Furthermore, results of in-vivo measurements obtained for various modes of operation of the system are presented.
影响因子：
3.8
作者：
Toronov, V;Franceschini, MA;Gratton, E
通讯作者：
Gratton, E