Chronic oxytocin administration in older men modulates functional connectivity during animacy perception.
Chronic oxytocin administration in older men modulates functional connectivity during animacy perception.
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DOI：
10.1016/j.nbas.2021.100023
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ebner, Natalie C.
中科院分区：
文献类型：
--
作者：
Valdes-Hernandez, Pedro A.;Polk, Rebecca;Horta, Marilyn;Frazier, Ian;Perez, Eliany;Ojeda, Marite;Porges, Eric;Cruz-Almeida, Yenisel;Feifel, David;Ebner, Natalie C.
关键词：
虽然衰老与社会认知变化有关，而催产素在社会认知中起着至关重要的作用，但催产素对老年人社会大脑的影响仍未得到充分研究。到目前为止，还没有研究检查慢性鼻内催产素对老年人动物感知的脑机制的影响。采用安慰剂对照、随机、双盲设计，在一般健康的老年男性(平均年龄（SD） = 69(6)；n = 17催产素;n = 14安慰剂)，本研究确定了在Heider-Simmel任务期间，4周鼻内给予催产素（24国际单位/每天两次）对功能MRI （fMRI）的影响。这种被动观看的动画感知范式包含简单形状的视频片段，暗示着社会互动（社会条件）或展示随机轨迹（随机条件）。虽然与随机条件相比，社会条件下没有催产素对大脑fMRI激活的特异性影响，但与安慰剂组相比，在覆盖枕区、颞区、顶叶区和颞上沟（动画感知的关键结构）的网络中，催产素对社会-随机功能连接差异（FC）的干预前和干预后的变化更高。这些发现表明催产素调节涉及动作观察和社会感知的回路。对该网络连接的后续分析表明，在安慰剂组中，干预前后FC的社会随机差异有所减少，这可能反映了对反复接触社会线索的习惯。慢性催产素似乎通过在随机条件下减少FC而在社会条件下增加FC来对抗这一过程。本研究对老年人社会脑中催产素的干预机制有了进一步的了解。
While aging is associated with social-cognitive change and oxytocin plays a crucial role in social cognition, oxytocin’s effects on the social brain in older age remain understudied. To date, no study has examined the effects of chronic intranasal oxytocin administration on brain mechanisms underlying animacy perception in older adults. Using a placebo-controlled, randomized, double-blinded design in generally healthy older men (mean age (SD) = 69(6); n = 17 oxytocin; n = 14 placebo), this study determined the effects of a four-week intranasal oxytocin administration (24 international units/twice a day) on functional MRI (fMRI) during the Heider-Simmel task. This passive-viewing animacy perception paradigm contains video-clips of simple shapes suggesting social interactions (SOCIAL condition) or exhibiting random trajectories (RANDOM condition). While there were no oxytocin-specific effects on brain fMRI activation during the SOCIAL compared to the RANDOM condition, pre-to-post intervention change in the SOCIAL-RANDOM difference in functional connectivity (FC) was higher in the oxytocin compared to the placebo group in a network covering occipital, temporal, and parietal areas, and the superior temporal sulcus, a key structure in animacy perception. These findings suggest oxytocin modulation of circuits involved in action observation and social perception. Follow-up analyses on this network’s connections suggested a pre-to-post intervention decrease in the SOCIAL-RANDOM difference in FC among the placebo group, possibly reflecting habituation to repeated exposure to social cues. Chronic oxytocin appeared to counter this process by decreasing FC during the RANDOM and increasing it during the SOCIAL condition. This study advances knowledge about oxytocin intervention mechanisms in the social brain of older adults.
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