Oxytocin and socioemotional aging: Current knowledge and future trends.
Oxytocin and socioemotional aging: Current knowledge and future trends.
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催产素和社会情感老化：当前的知识和未来趋势。
DOI：
10.3389/fnhum.2013.00487
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发表时间：
2013
影响因子：
2.9
通讯作者：
Fischer H
中科院分区：
文献类型：
--
作者：
Ebner NC;Maura GM;Macdonald K;Westberg L;Fischer H
催产素（OT）系统参与社会认知和亲社会行为的各个方面。具体而言，OT已被检查的背景下，社会记忆，情感识别，合作，信任，同情和债券，虽然证据是有点混合鼻内OT似乎有利于社会情绪功能方面。然而，大多数关于衰老和OT的现存数据来自动物研究，而人类OT研究主要集中在年轻人身上。因此，尽管我们知道各种社会情绪能力随着年龄的变化而变化，但我们对OT系统中与年龄相关的变化是否可能是社会情绪功能与年龄相关的差异的基础知之甚少。在这篇综述中，我们采取了遗传神经行为的方法，并评估目前的证据与年龄相关的变化，在OT系统，以及这些变化对年龄相关的社会情绪功能的推定影响。展望未来，我们确定了信息差距，并提出了一个与年龄相关的遗传，神经生物学，催产素的社会行为模型（AGeNeS-OT模型），该模型可以构建并告知与OT相关的衰老相关的遗传，神经和社会认知过程的调查。作为使用该模型的一个范例，我们报告的探索性数据表明，在年轻人和老年人的样本中，催产素受体基因（OXTR）的遗传变异与社会情绪处理的差异。从这个竞技场中获得的信息在抑郁、社会压力和焦虑方面具有转化潜力，所有这些都与衰老高度相关，并且可能有助于减少社会孤立和改善个人的终身幸福。
The oxytocin (OT) system is involved in various aspects of social cognition and prosocial behavior. Specifically, OT has been examined in the context of social memory, emotion recognition, cooperation, trust, empathy, and bonding, and—though evidence is somewhat mixed-intranasal OT appears to benefit aspects of socioemotional functioning. However, most of the extant data on aging and OT is from animal research and human OT research has focused largely on young adults. As such, though we know that various socioemotional capacities change with age, we know little about whether age-related changes in the OT system may underlie age-related differences in socioemotional functioning. In this review, we take a genetic-neuro-behavioral approach and evaluate current evidence on age-related changes in the OT system as well as the putative effects of these alterations on age-related socioemotional functioning. Looking forward, we identify informational gaps and propose an Age-Related Genetic, Neurobiological, Sociobehavioral Model of Oxytocin (AGeNeS-OT model) which may structure and inform investigations into aging-related genetic, neural, and sociocognitive processes related to OT. As an exemplar of the use of the model, we report exploratory data suggesting differences in socioemotional processing associated with genetic variation in the oxytocin receptor gene (OXTR) in samples of young and older adults. Information gained from this arena has translational potential in depression, social stress, and anxiety-all of which have high relevance in aging—and may contribute to reducing social isolation and improving well-being of individuals across the lifespan.
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影响因子：
8.2
作者：
Bartz JA;Zaki J;Bolger N;Hollander E;Ludwig NN;Kolevzon A;Ochsner KN
通讯作者：
Ochsner KN
影响因子：
2.9
作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
通讯作者：
BERTOLINI, A
DOI：
10.1037/0096-1523.26.2.527
发表时间：
2000-04-01
影响因子：
2.1
作者：
Calder, AJ;Young, AW;Dean, M
通讯作者：
Dean, M
影响因子：
3.7
作者：
Carstensen LL;Turan B;Scheibe S;Ram N;Ersner-Hershfield H;Samanez-Larkin GR;Brooks KP;Nesselroade JR
通讯作者：
Nesselroade JR
影响因子：
2.3
作者：
Barraza, Jorge A.;Grewal, Naomi S.;Zak, Paul J.
通讯作者：
Zak, Paul J.