Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella-based trophic network.
Gut microbiomes from Gambian infants reveal the development of a non-industrialized Prevotella-based trophic network.
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DOI：
10.1038/s41564-021-01023-6
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发表时间：
2022-01
影响因子：
28.3
通讯作者：
Wagner J
中科院分区：
文献类型：
--
作者：
de Goffau MC;Jallow AT;Sanyang C;Prentice AM;Meagher N;Price DJ;Revill PA;Parkhill J;Pereira DIA;Wagner J
不同的细菌营养网络存在于工业化和非工业化国家个体的肠道微生物群中。特别是，非工业化的肠道微生物组往往富含普雷沃氏菌属物种。为了研究这些富含普雷沃泰拉的组合物的发展，我们调查了生活在冈比亚农村的7至37个月儿童的肠道微生物群（616名儿童，1，389份粪便样本，按3个月年龄组分层）。这些婴儿通常吃高纤维，低蛋白饮食，是双盲，随机铁干预试验（NCT 02941081）的一部分，在这里我们报告次要结局。我们发现，儿童年龄是样本之间最大的区分因素，人体测量指标（收集时间点，季节，地理收集地点和铁补充剂）并没有显着影响肠道微生物组。在这1，389个样本中，平均而言，普雷沃氏菌、普氏粪杆菌和粪普雷沃氏菌是最丰富的物种（分别为35%、11%和7%）。不同的细菌营养网络集群进行了鉴定，围绕P. stercorea或F。prausnitzii和被发现随着年龄的增长而稳定发展，而P. copri，独立于其他物种，在断奶后迅速成为优势。该数据集设置在关键的肠道微生物发育时间范围内，提供了对富含普雷沃菌的肠道微生物组的发展的见解，这些肠道微生物组通常未得到充分研究，并且在西方人群中代表性不足。冈比亚婴儿肠道微生物组的分析揭示了基于普雷沃氏菌属物种的细菌营养网络，这些物种通常在非工业化人群中富集。
Distinct bacterial trophic networks exist in the gut microbiota of individuals in industrialized and non-industrialized countries. In particular, non-industrialized gut microbiomes tend to be enriched with Prevotella species. To study the development of these Prevotella-rich compositions, we investigated the gut microbiota of children aged between 7 and 37 months living in rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part of a double-blind, randomized iron intervention trial (NCT02941081) and here we report the secondary outcome. We found that child age was the largest discriminating factor between samples and that anthropometric indices (collection time points, season, geographic collection site, and iron supplementation) did not significantly influence the gut microbiome. Prevotella copri, Faecalibacterium prausnitzii and Prevotella stercorea were, on average, the most abundant species in these 1,389 samples (35%, 11% and 7%, respectively). Distinct bacterial trophic network clusters were identified, centred around either P. stercorea or F. prausnitzii and were found to develop steadily with age, whereas P. copri, independently of other species, rapidly became dominant after weaning. This dataset, set within a critical gut microbial developmental time frame, provides insights into the development of Prevotella-rich gut microbiomes, which are typically understudied and are underrepresented in western populations. Analysis of gut microbiomes from Gambian infants reveals bacterial trophic networks based around Prevotella species, which are typically enriched in non-industrialized populations.
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影响因子：
4.3
作者：
Mallick H;Rahnavard A;McIver LJ;Ma S;Zhang Y;Nguyen LH;Tickle TL;Weingart G;Ren B;Schwager EH;Chatterjee S;Thompson KN;Wilkinson JE;Subramanian A;Lu Y;Waldron L;Paulson JN;Franzosa EA;Bravo HC;Huttenhower C
通讯作者：
Huttenhower C
影响因子：
14.9
作者：
Ludwig, W;Strunk, O;Schleifer, KH
通讯作者：
Schleifer, KH
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
15.5
作者：
Gorvitovskaia A;Holmes SP;Huse SM
通讯作者：
Huse SM
影响因子：
4.6
作者：
Nagpal, Ravinder;Kurakawa, Takashi;Yamashiro, Yuichiro
通讯作者：
Yamashiro, Yuichiro