The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
The vitamin D-antimicrobial peptide pathway and its role in protection against infection.
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DOI：
10.2217/fmb.09.87
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发表时间：
2009-11
影响因子：
3.1
通讯作者：
Gombart AF
中科院分区：
文献类型：
--
作者：
Gombart AF
维生素D缺乏与感染率增加有关。自19世纪初以来，环境（即，阳光）和饮食来源（鳕鱼肝）的维生素D已被确定为结核病的治疗方法。最近发现维生素D诱导抗菌肽基因表达，部分解释了维生素D的“抗生素”作用，并极大地重新关注维生素D改善免疫功能的能力。随后的工作表明，这种调节对于先天免疫系统对伤口和感染的反应具有生物学重要性，并且这种缺陷可能导致对细菌和病毒感染的次优反应。凯萨林菌素抗菌肽基因的调节是人类/灵长类动物特异性适应，在其他哺乳动物中不保守。维生素D受体作为维生素D的高亲和力受体和次级胆汁酸和潜在的其他新型营养化合物的低亲和力受体的能力表明，将凯萨林菌素基因置于维生素D受体控制下的进化选择允许其在内分泌和外源性反应系统下进行调节。未来在人类和人源化小鼠模型中的研究将阐明这种调节的重要性，并导致潜在治疗应用的发展。
Vitamin D deficiency has been correlated with increased rates of infection. Since the early 19th century, both environmental (i.e., sunlight) and dietary sources (cod liver) of vitamin D have been identified as treatments for TB. The recent discovery that vitamin D induces antimicrobial peptide gene expression explains, in part, the ‘antibiotic’ effect of vitamin D and has greatly renewed interest in the ability of vitamin D to improve immune function. Subsequent work indicates that this regulation is biologically important for the response of the innate immune system to wounds and infection and that deficiency may lead to suboptimal responses toward bacterial and viral infections. The regulation of the cathelicidin antimicrobial peptide gene is a human/primate-specific adaptation and is not conserved in other mammals. The capacity of the vitamin D receptor to act as a high-affinity receptor for vitamin D and a low-affinity receptor for secondary bile acids and potentially other novel nutritional compounds suggests that the evolutionary selection to place the cathelicidin gene under control of the vitamin D receptor allows for its regulation under both endocrine and xenobiotic response systems. Future studies in both humans and humanized mouse models will elucidate the importance of this regulation and lead to the development of potential therapeutic applications.
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影响因子：
82.9
作者：
Chromek, Milan;Slamova, Zuzana;Brauner, Annelie
通讯作者：
Brauner, Annelie
影响因子：
4.4
作者：
Boonstra, A;Barrat, FJ;O'Garra, A
通讯作者：
O'Garra, A
影响因子：
4.3
作者：
Adorini, L
通讯作者：
Adorini, L
DOI：
10.1016/0041-3879(85)90068-6
发表时间：
1985-01-01
期刊：
TUBERCLE
影响因子：
--
作者：
DAVIES, PDO
通讯作者：
DAVIES, PDO
影响因子：
6.1
作者：
Anderson, E;Sorensen, OE;Malm, J
通讯作者：
Malm, J