The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats.
The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats.
复制标题
DOI：
10.1016/j.brainres.2008.07.001
复制
发表时间：
2008-09-10
期刊：
影响因子：
2.9
通讯作者：
Dougherty, Patrick M.
中科院分区：
文献类型：
--
作者：
Cata, Juan P.;Weng, Han-Rong;Dougherty, Patrick M.
化疗引起的疼痛是接受紫杉烷、长春花生物碱或铂类药物化疗的癌症患者遇到的最常见的治疗限制性并发症。多项证据表明，涉及细胞因子（包括肿瘤坏死因子-α（TNF-α）、白细胞介素-1 β（IL-1β）和白细胞介素-6（IL-6））以及各种生长因子释放的促炎级联反应的激活是许多类型神经损伤相关疼痛发病机制中的关键事件。类似的机制也可能参与化疗引起的疼痛的病因学。沙利度胺和米诺环素除了其最初预期的药理作用外，还具有深刻的免疫调节作用。本文评价了这些化合物在预防大鼠中紫杉醇诱导的机械和热痛觉过敏的发展中的作用。沙利度胺（50.0 mg/kg）减少紫杉醇诱导的机械性异常性疼痛和痛觉过敏，而米诺环素（20.0 mg/kg）减少紫杉醇诱导的机械性痛觉过敏和异常性疼痛以及紫杉醇诱导的热痛觉过敏。这些结果表明，免疫调节剂可能提供一种治疗选择的保护或逆转化疗相关的疼痛。
Chemotherapy-induced pain is the most common treatment-limiting complication encountered by cancer patients receiving taxane-, vinca alkaloid- or platin-based chemotherapy. Several lines of evidence indicate that activation of pro-inflammatory cascades involving the release of cytokines including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) as well as various growth factors are key events in the pathogenesis of many types of nerve-injury related pain. Similar mechanisms might also be involved in the etiology of chemotherapy-induced pain. Thalidomide and minocycline have profound immunomodulatory actions in addition to their originally intended pharmacological actions. These compounds were evaluated here for effects in preventing the development of taxol-induced mechanical and thermal hyperalgesia in rats. Thalidomide (50.0 mg/kg) reduced taxol-induced mechanical allodynia and hyperalgesia whereas minocycline (20.0 mg/kg) reduced taxol-induced mechanical hyperalgesia and allodynia as well as taxol-induced thermal hyperalgesia. These results suggest that immunomodulatory agents may provide a treatment option for the protection or reversal of chemotherapy-related pain.
登录
查看更多内容
影响因子：
2.9
作者：
Arruda, JL;Sweitzer, SA;DeLeo, JA
通讯作者：
DeLeo, JA
DOI：
10.1016/s0190-9622(84)80458-2
发表时间：
1984-01-01
影响因子：
13.8
作者：
BARNHILL, RL;DOLL, NJ;HASTINGS, RC
通讯作者：
HASTINGS, RC
影响因子：
56.9
作者：
DING, AH;PORTEU, F;NATHAN, CF
通讯作者：
NATHAN, CF
影响因子：
4.8
作者：
Keifer, JA;Guttridge, DC;Baldwin, AS
通讯作者：
Baldwin, AS
影响因子：
1.7
作者：
Bao, L;Zhu, Y;Lindgren, JU
通讯作者：
Lindgren, JU