Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).
Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx).
复制标题
DOI：
10.1126/science.1176620
复制
发表时间：
2009-10-16
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Xia Q;Guo Y;Zhang Z;Li D;Xuan Z;Li Z;Dai F;Li Y;Cheng D;Li R;Cheng T;Jiang T;Becquet C;Xu X;Liu C;Zha X;Fan W;Lin Y;Shen Y;Jiang L;Jensen J;Hellmann I;Tang S;Zhao P;Xu H;Yu C;Zhang G;Li J;Cao J;Liu S;He N;Zhou Y;Liu H;Zhao J;Ye C;Du Z;Pan G;Zhao A;Shao H;Zeng W;Wu P;Li C;Pan M;Li J;Yin X;Li D;Wang J;Zheng H;Wang W;Zhang X;Li S;Yang H;Lu C;Nielsen R;Zhou Z;Wang J;Xiang Z;Wang J
从40个家蚕和野生家蚕中构建了单碱基对分辨遗传变异图谱，每个家蚕的序列覆盖率约为3倍，占基因组的99.88%。我们鉴定了∼1600万个单核苷酸多态、许多INDELs和结构变异。我们发现，家蚕与野生家蚕在遗传上有明显的区别，但它们保持了很高的遗传变异水平，这表明驯化事件涉及大量的个体。我们还在354个候选基因中确定了选择的信号，这些基因在驯化过程中可能是重要的，其中一些在丝腺、中肠和睾丸中丰富表达。这些数据增加了我们对家蚕驯化过程的了解，并可能在制定虫害控制策略和促进家蚕作为高效生物反应器的使用方面有所应用。
A single–base pair resolution silkworm genetic variation map was constructed from 40 domesticated and wild silkworms, each sequenced to approximately threefold coverage, representing 99.88% of the genome. We identified ∼16 million single-nucleotide polymorphisms, many indels, and structural variations. We find that the domesticated silkworms are clearly genetically differentiated from the wild ones, but they have maintained large levels of genetic variability, suggesting a short domestication event involving a large number of individuals. We also identified signals of selection at 354 candidate genes that may have been important during domestication, some of which have enriched expression in the silk gland, midgut, and testis. These data add to our understanding of the domestication processes and may have applications in devising pest control strategies and advancing the use of silkworms as efficient bioreactors.
登录
查看更多内容
影响因子：
3.1
作者：
Li, MW;Shen, L;Huang, YP
通讯作者：
Huang, YP
影响因子：
3.8
作者：
Xia, Qingyou;Wang, Jun;Morishita, Shinichi
通讯作者：
Morishita, Shinichi
亚洲个体的二倍体基因组序列
影响因子：
64.8
作者：
Wang, Jun;Wang, Wei;Li, Ruiqiang;Li, Yingrui;Tian, Geng;Goodman, Laurie;Fan, Wei;Zhang, Junqing;Li, Jun;Zhang, Juanbin;Guo, Yiran;Feng, Binxiao;Li, Heng;Lu, Yao;Fang, Xiaodong;Liang, Huiqing;Du, Zhenglin;Li, Dong;Zhao, Yiqing;Hu, Yujie;Yang, Zhenzhen;Zheng, Hancheng;Hellmann, Ines;Inouye, Michael;Pool, John;Yi, Xin;Zhao, Jing;Duan, Jinjie;Zhou, Yan;Qin, Junjie;Ma, Lijia;Li, Guoqing;Yang, Zhentao;Zhang, Guojie;Yang, Bin;Yu, Chang;Liang, Fang;Li, Wenjie;Li, Shaochuan;Li, Dawei;Ni, Peixiang;Ruan, Jue;Li, Qibin;Zhu, Hongmei;Liu, Dongyuan;Lu, Zhike;Li, Ning;Guo, Guangwu;Zhang, Jianguo;Ye, Jia;Fang, Lin;Hao, Qin;Chen, Quan;Liang, Yu;Su, Yeyang;San, A.;Ping, Cuo;Yang, Shuang;Chen, Fang;Li, Li;Zhou, Ke;Zheng, Hongkun;Ren, Yuanyuan;Yang, Ling;Gao, Yang;Yang, Guohua;Li, Zhuo;Feng, Xiaoli;Kristiansen, Karsten;Wong, Gane Ka-Shu;Nielsen, Rasmus;Durbin, Richard;Bolund, Lars;Zhang, Xiuqing;Li, Songgang;Yang, Huanming;Wang, Jian
通讯作者：
Wang, Jian
DOI：
10.1098/rspb.2004.2971
发表时间：
2005-02-07
影响因子：
4.7
作者：
Marcillac, F;Grosjean, Y;Ferveur, JF
通讯作者：
Ferveur, JF
影响因子：
4.6
作者：
Abrams, Elliott W.;Mihoulides, Whitney K.;Andrew, Deborah J.
通讯作者：
Andrew, Deborah J.