Stem cell-based strategies for the treatment of type 1 diabetes mellitus.
Stem cell-based strategies for the treatment of type 1 diabetes mellitus.
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DOI：
10.1517/14712598.2011.540235
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发表时间：
2011-01
影响因子：
4.6
通讯作者：
Ildstad ST
中科院分区：
文献类型：
--
作者：
Wen Y;Chen B;Ildstad ST
胰岛β细胞再生和胰岛β细胞保存是治疗1型糖尿病(T1D)的两种有前景的治疗方法。基于干细胞的策略，以解决β细胞、自身免疫和同种异体免疫反应不足的问题，已成为一个密集的研究领域。本文综述了从不同类型的干/祖细胞中获取功能性胰岛素分泌细胞的研究进展，包括造血干细胞和多能基质细胞在治疗T1D中的免疫调节作用的研究现状。对这一领域的最新进展进行了广泛的概述。讨论了在使用干细胞为基础的策略治疗T1D的道路上仍然存在的障碍以及克服这些挑战的可能方法。以干细胞为基础的策略为治疗T1D带来了巨大的希望。尽管在过去的十年里已经取得了进展，但在广泛的临床应用之前，需要清除一些障碍和担忧。特别是，ESC和IPSC来源的β细胞在体内成熟的机制还知之甚少。
Beta cell regeneration and beta cell preservation are two promising therapeutic approaches for the management of patients with Type 1 diabetes (T1D). Stem cell-based strategies to address the problems of shortage in beta cells, autoimmune and alloimmune responses have become an area of intense study. This review focuses on the progress that has been made in obtaining functional, insulin-producing cells from various types of stem/progenitor cells, including the current knowledge on the immunomodulatory roles of hematopoietic stem cell and multipotent stromal cell in the therapies for T1D. A broad overview of recent advancements in this field is provided. The hurdles that remain in the path of using stem cell-based strategies for the treatment of T1D and possible approaches to overcome these challenges are discussed. Stem cell-based strategies hold great promise for the treatment of T1D. In spite of the progress that has been made over the last decade, a number of obstacles and concerns need to be cleared before widespread clinical application is possible. In particular, the mechanism of ESC and iPSC-derived beta cell maturation in vivo is poorly understood.
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影响因子：
56.9
作者：
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通讯作者：
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作者：
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通讯作者：
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20.3
作者：
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通讯作者：
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