Pathway-based metabolomics study of sarcopenia-related traits in two US cohorts.
Pathway-based metabolomics study of sarcopenia-related traits in two US cohorts.
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DOI：
10.18632/aging.203926
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发表时间：
2022-03-02
期刊：
影响因子：
--
通讯作者：
Deng HW
中科院分区：
文献类型：
--
作者：
Zhao Q;Shen H;Liu J;Chiu CY;Su KJ;Tian Q;Kakhniashvili D;Qiu C;Zhao LJ;Luo Z;Deng HW
我们的目的是验证两种代谢物，天冬氨酸和谷氨酸，这是与肌肉减少症相关的性状，肌肉质量和力量，在我们以前的非靶向代谢组学研究，并确定新的代谢物从五个代谢途径涉及这两种代谢物。我们纳入了一个由136名年龄在20-40岁之间的白色女性组成的发现队列（用于既往非靶向代谢组学分析）和一个由174名年龄≥ 60岁的受试者组成的验证队列，包括白色和黑人男性和女性。靶向LC-MS分析成功检测到来自这些途径的12种重要代谢物。在发现队列中，天冬氨酸与肌肉质量和力量相关，但在验证队列中不相关。然而，在两个队列中，谷氨酸与这些肌肉减少症特征相关。此外，N-乙酰基-L-天冬氨酸和肌肽分别是发现和验证队列中新鉴定的与肌肉力量相关的代谢物。在验证队列中，我们没有观察到这些代谢物与肌肉减少症特征之间存在任何显著的性别和种族差异。我们的研究结果表明，谷氨酸可能始终与年龄，性别和种族的少肌症相关的特征。他们还表明，年龄特异性代谢物和代谢途径可能参与肌肉调节。
We aimed to validate two metabolites, aspartic acid and glutamic acid, which were associated with sarcopenia-related traits, muscle mass and strength, in our previous untargeted metabolomics study and to identify novel metabolites from five metabolic pathways involving these two metabolites. We included a discovery cohort of 136 white women aged 20-40 years (used for the previous untargeted metabolomics analysis) and a validation cohort of 174 subjects aged ≥ 60 years, including men and women of white and black. A targeted LC-MS assay successfully detected 12 important metabolites from these pathways. Aspartic acid was associated with muscle mass and strength in the discovery cohort, but not in the validation cohort. However, glutamic acid was associated with these sarcopenia traits in both cohorts. Additionally, N-acetyl-L-aspartic acid and carnosine were the newly identified metabolites that were associated with muscle strength in the discovery and validation cohorts, respectively. We did not observe any significant sex and race differences in the associations of these metabolites with sarcopenia traits in the validation cohort. Our findings indicated that glutamic acid might be consistently associated with sarcopenia-related traits across age, sex, and race. They also suggested that age-specific metabolites and metabolic pathways might be involved in muscle regulation.
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影响因子：
4
作者：
He, H.;Liu, Y.;Deng, H. -W.
通讯作者：
Deng, H. -W.
影响因子：
3.2
作者：
Liu, Yulan;Wang, Xiuying;Hu, Chien-An Andy
通讯作者：
Hu, Chien-An Andy
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.2
作者：
Gertsman I;Barshop BA
通讯作者：
Barshop BA
影响因子：
6.1
作者：
Costa, Christopher;Maraschin, Marcelo;Rocha, Miguel
通讯作者：
Rocha, Miguel