Racial disparities in frailty and geriatric assessment impairments in older adults with cancer in the Deep South: Results from the CARE Registry.
Racial disparities in frailty and geriatric assessment impairments in older adults with cancer in the Deep South: Results from the CARE Registry.
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南方腹地癌症老年患者的虚弱和老年评估损害方面的种族差异：来自CARE登记的结果。
DOI：
10.1002/cncr.34178
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发表时间：
2022-06-15
期刊：
影响因子：
6.2
通讯作者：
Giri, Smith
中科院分区：
文献类型：
--
作者：
Williams, Grant R.;Al-Obaidi, Mustafa;Harmon, Christian;Dai, Chen;Outlaw, Darryl;Gbolahan, Olumide;Khushman, Moh'd;Nyrop, Kirsten A.;Gilmore, Nikesha;Bhatia, Smita;Giri, Smith
尽管最近的癌症进展，治疗结果的种族差异仍然存在，其机制仍不完全清楚。我们的目的是研究一个新诊断的胃肠道（GI）恶性肿瘤老年人队列中虚弱和老年评估（GA）障碍的种族差异。我们使用了来自癌症衰老和恢复力评估（CARE）登记处的数据，这是一项前瞻性队列研究，招募了患有GI恶性肿瘤的老年人（≥ 60岁）进行初步咨询。我们纳入了在化疗开始前完成GA并自我报告为白色或黑色的参与者。使用基于赤字累积方法的虚弱指数定义虚弱。我们研究了黑人和白色受试者之间虚弱和GA损伤的患病率和校正比值比的差异。在710名合格患者中，553名患者同意提供足够的数据进行分析。平均入组年龄为70± 7.1岁，58%为男性，23%为黑人。原发性癌症诊断包括结直肠癌（32%）、胰腺癌（27%）和肝胆癌（18%）。黑人参与者更有可能身体虚弱（50.0% vs. 32.7%，p<0.001）并报告日常生活活动受限（27.3% vs. 14.1%，p=0.001）、工具性日常生活活动（64.38% vs. 47.3%，p=0.002）和步行一个街区（62.5% vs. 48.2%，p=0.004）。即使在调整了年龄、性别、教育、癌症类型、癌症分期和合并症后，这些相关性仍然存在。与白色参与者相比，黑人参与者更加虚弱，并且报告功能受到更多限制。这些发现可能部分解释了癌症结果的差异，并需要进一步研究。
Despite recent cancer advances, racial disparities in treatment outcomes persist, the mechanisms for which are still not fully understood. Our objective was to examine racial differences in frailty and geriatric assessment (GA) impairments in an unselected cohort older adults with newly diagnosed gastrointestinal (GI) malignancies. We used data from the Cancer Aging and Resilience Evaluation (CARE) registry, a prospective cohort study that enrolled older adults (≥60y) with GI malignancies presenting for initial consultation. We included participants with GA completed prior to chemotherapy initiation and self-reported as either White or Black. Frailty was defined using a frailty index based on the deficit accumulation method. We examined the differences in prevalence and adjusted odds ratio for frailty and GA impairments between Black and White participants. Of 710 eligible patients seen, 553 consented with sufficient data for analyses. Mean age enrollment of 70±7.1y, 58% were male and 23% were Black. Primary cancer diagnoses included colorectal cancer (32%), pancreatic cancer (27%), and hepatobiliary cancer (18%). Black participants were more likely to be frail (50.0% vs. 32.7%, p<0.001) and report limitations in activities of daily living (27.3% vs. 14.1%, p=0.001), instrumental activities of daily living (64.38% vs. 47.3%, p=0.002), and walking one block (62.5% vs. 48.2%, p=0.004). These associations persisted even after adjustment for age, sex, education, cancer type, cancer stage, and comorbidity. Black participants were more frail and reported more limitations in function compared to White participants. These findings may partially explain disparities in cancer outcomes and warrant further examination.
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影响因子：
5.5
作者：
Stepanikova I;Bateman LB;Oates GR
通讯作者：
Oates GR
DOI：
10.1093/geronb/57.5.s275
发表时间：
2002-09-01
影响因子：
6.2
作者：
Fleishman, JA;Spector, WD;Altman, BM
通讯作者：
Altman, BM
影响因子：
45.3
作者：
Patel, Manali I.;Lopez, Ana Maria;Tap, William
通讯作者：
Tap, William
影响因子：
3.2
作者：
Bhatia, Smita
通讯作者：
Bhatia, Smita
DOI：
10.1111/j.1532-5415.2007.01186.x
发表时间：
2007-06-01
影响因子：
6.3
作者：
Leng, Sean X.;Xue, Qian-Li;Fried, Linda P.
通讯作者：
Fried, Linda P.