Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn's disease complicated with inflammatory mass.
Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn's disease complicated with inflammatory mass.
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多次新鲜粪便微生物群移植可诱导并维持克罗恩病并发炎性肿块的临床缓解
DOI：
10.1038/s41598-017-04984-z
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发表时间：
2017-07-06
影响因子：
4.6
通讯作者：
Zhang F
中科院分区：
文献类型：
--
作者：
He Z;Li P;Zhu J;Cui B;Xu L;Xiang J;Zhang T;Long C;Huang G;Ji G;Nie Y;Wu K;Fan D;Zhang F
中国古代医学文献以及我们以前的临床经验表明，粪便微生物群移植（FMT）可以治疗炎性肿块。我们的目的是评价多种新鲜FMT治疗克罗恩病（CD）合并腹腔炎性肿块的有效性和安全性。所有患者均遵循“1小时FMT方案”。25例患者经CT或MRI诊断为CD及相关炎性肿块。所有患者均接受初始FMT，随后每3个月重复FMT。主要终点是临床应答（改善和缓解）和12个月时的持续临床缓解。次要终点是基于横截面成像和FMT安全性的肺门/脓肿大小的改善。在首次FMT后3个月，分别有68.0%（17/25）和52.0%（13/25）的患者达到临床应答和临床缓解。序贯FMT治疗后6个月、12个月和18个月达到持续临床缓解的患者比例分别为48.0%（12/25）、32.0%（8/25）和22.7%（5/22）。9.5%（2/21）的患者达到放射学愈合，71.4%（15/21）的患者达到放射学改善。未观察到与FMT相关的严重不良事件。这项务实的研究表明，序贯新鲜FMT可能是一个有前途的，安全和有效的治疗，以诱导和维持临床缓解CD腹腔内炎性肿块。
The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn’s disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months. The primary endpoint was clinical response (improvement and remission) and sustained clinical remission at 12 months. Secondary endpoints were improvement in size of phegmon/abscess based upon cross-sectional imaging and safety of FMT. 68.0% (17/25) and 52.0% (13/25) of patients achieved clinical response and clinical remission at 3 months post the initial FMT, respectively. The proportion of patients at 6 months, 12 months and 18 months achieving sustained clinical remission with sequential FMTs was 48.0% (12/25), 32.0% (8/25) and 22.7% (5/22), respectively. 9.5% (2/21) of patients achieved radiological healing and 71.4% (15/21) achieved radiological improvement. No severe adverse events related to FMT were observed. This pragmatic study suggested that sequential fresh FMTs might be a promising, safe and effective therapy to induce and maintain clinical remission in CD with intraabdominal inflammatory mass.
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影响因子：
12.2
作者：
Cui B;Li P;Xu L;Peng Z;Xiang J;He Z;Zhang T;Ji G;Nie Y;Wu K;Fan D;Zhang F
通讯作者：
Zhang F
影响因子：
7.4
作者：
Cui B;Li P;Xu L;Zhao Y;Wang H;Peng Z;Xu H;Xiang J;He Z;Zhang T;Nie Y;Wu K;Fan D;Ji G;Zhang F
通讯作者：
Zhang F
影响因子：
1.6
作者：
Zhu J;Zhang F;Luan Y;Cao P;Liu F;He W;Wang D
通讯作者：
Wang D
影响因子：
5.4
作者：
Khosravi A;Mazmanian SK
通讯作者：
Mazmanian SK
影响因子：
29.4
作者：
Moayyedi, Paul;Surette, Michael G.;Lee, Christine H.
通讯作者：
Lee, Christine H.