Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity.
Single muscle fiber adaptations to resistance training in old (>80 yr) men: evidence for limited skeletal muscle plasticity.
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老年（> 80 岁）男性单肌纤维对阻力训练的适应：骨骼肌可塑性有限的证据。
DOI：
10.1152/ajpregu.00093.2008
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Trappe,Scott
中科院分区：
文献类型：
--
作者：
Slivka,Dustin;Raue,Ulrika;Hollon,Chris;Minchev,Kiril;Trappe,Scott
这项研究的目的是调查高龄男性对渐进性阻力训练(PRT)的整体肌肉和单一肌肉纤维的适应情况。6名独立生活的健康老年男性(82±1岁，范围80~86岁，74±4 kg)进行膝关节伸肌(3套，10次)抗阻训练，∼70%，1次/wk，最大3d/wk，共12wk。采用计算机断层扫描(CT)测量PRT前后大腿全肌横截面积(CSA)。在PRT计划之前和之后从股外侧肌获得肌肉活组织检查。对分离的肌球蛋白重链(MHC)I和IIa单肌纤维(n=267；142 Pre；125 Post)的直径、峰值张力、缩短速度和功率进行了研究。另一组分离的单一肌肉纤维(n=2215；1202pre1,013 post)用于鉴定MHC的分布。一次重复最大伸膝力量增加(P<；0.05)23±4公斤(56±4至79±7公斤；41%)。肌肉CSA增加(P<；0.05)3±1cm2(120±7至123±7cm2；2.5%)。PRT对单个肌纤维收缩功能和MHC分布无明显影响。这些数据表明，在老年人中，通过阻力训练计划，单一肌肉纤维水平的肌肉可塑性有限。整个肌肉CSA的轻微增加，加上肌细胞轮廓的静态性质，表明力量的增加主要是神经方面的。这些数据对比了年轻人(∼20岁)和老年人(∼70岁)对阻力训练的典型肌肉反应，表明肌肉重塑的生理调节在年龄最大的老年人中发生了不利的改变。
The purpose of this study was to investigate whole muscle and single muscle fiber adaptations in very old men in response to progressive resistance training (PRT). Six healthy independently living old men (82 ± 1 yr; range 80–86 yr, 74 ± 4 kg) resistance-trained the knee extensors (3 sets, 10 repetitions) at ∼70% one repetition maximum 3 days/wk for 12 wk. Whole thigh muscle cross-sectional area (CSA) was assessed before and after PRT using computed tomography (CT). Muscle biopsies were obtained from the vastus lateralis before and after the PRT program. Isolated myosin heavy chain (MHC) I and IIa single muscle fibers (n= 267; 142 pre; 125 post) were studied for diameter, peak tension, shortening velocity, and power. An additional set of isolated single muscle fibers (n= 2,215; 1,202 pre; 1,013 post) was used to identify MHC distribution. One repetition maximum knee extensor strength increased (P< 0.05) 23 ± 4 kg (56 ± 4 to 79 ± 7 kg; 41%). Muscle CSA increased (P< 0.05) 3 ± 1 cm2(120 ± 7 to 123 ± 7 cm2; 2.5%). Single muscle fiber contractile function and MHC distribution were unaltered with PRT. These data indicate limited muscle plasticity at the single-muscle fiber level with a resistance-training program among the very old. The minor increases in whole muscle CSA coupled with the static nature of the myocellular profile indicate that the strength gains were primarily neurological. These data contrast typical muscle responses to resistance training in young (∼20 yr) and old (∼70 yr) humans and indicate that the physiological regulation of muscle remodeling is adversely modified in the oldest old.
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卧床休息 17 天后人比目鱼肌纤维的力-速度-功率和力-PCA 关系。
影响因子：
3.3
作者：
J. Widrick;K. Norenberg;J. Romatowski;C. Blaser;M. Karhánek;J. Sherwood;S. Trappe;T. Trappe;D. Costill;R. Fitts
通讯作者：
R. Fitts
影响因子：
3.3
作者：
FITTS, RH;COSTILL, DL;GARDETTO, PR
通讯作者：
GARDETTO, PR
DOI：
10.1249/01.mss.0000232022.21361.47
发表时间：
2006-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Malisoux, Laurent;Francaux, Marc;Theisen, Daniel
通讯作者：
Theisen, Daniel
影响因子：
3
作者：
DANNESKIOLDSAMSOE, B;KOFOD, V;JENSEN, G
通讯作者：
JENSEN, G
肌肉力量增益时间过程中的神经因素与肥大。
DOI：
--
发表时间：
1979
期刊：
American Journal of Physical Medicine
影响因子：
--
作者：
T. Moritani;D. Ha
通讯作者：
D. Ha