Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.
Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.
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DOI：
10.1111/ner.13512
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发表时间：
2023-07
期刊：
影响因子：
--
通讯作者：
DaSilva AF
中科院分区：
文献类型：
--
作者：
Lim M;Kim DJ;Nascimento TD;Ichesco E;Kaplan C;Harris RE;DaSilva AF
虽然初级运动皮层（M1）经颅直流电刺激（tDCS）对纤维肌痛（FM）有镇痛作用，但其神经机制尚不清楚。我们研究了M1-tDCS是否调节血氧水平依赖性（BOLD）信号的区域时间变异性，这是大脑灵活性和效率的指标，以及这种变化是否与疼痛改善相关。在受试者内交叉设计中，12例女性FM患者分别连续5天接受假手术和活性tDCS。每次会话均在左侧M1上放置阳极，在对侧眶上区域放置阴极。受试者还在基线和假手术和活动tDCS后参加了静息态功能磁共振成像（fMRI）。我们比较了tDCS条件之间的BOLD信号变异性（SDBOLD），定义为BOLD时间序列的标准差。将基线SDBOLD与15名健康女性对照进行比较。基线时，与健康对照组相比，FM患者的腹内侧前额叶皮质（vmPFC）、外侧PFC和前岛的SDBOLD减少，而后岛的SDBOLD增加。与假手术组相比，活动性tDCS后，我们发现左喙前扣带皮层（rACC）、外侧PFC和丘脑中的SDBOLD增加。在假tDCS后，与基线相比，我们发现背内侧PFC和后扣带回皮质/楔前叶的SDBOLD降低。有趣的是，与假手术相比，主动tDCS后，疼痛减轻与rACC/vmPFC中SDBOLD增加相关，但与后额叶SDBOLD降低相关。我们的研究结果表明，M1-tDCS可能会恢复与FM疼痛相关的rACC/vmPFC和后前脑的fMRI信号的时间变异性。神经变异性的变化可能是FM中重复M1-tDCS镇痛的机制的一部分。
Although primary motor cortex (M1) transcranial direct current stimulation (tDCS) has an analgesic effect in fibromyalgia (FM), its neural mechanism remains elusive. We investigated whether M1-tDCS modulates a regional temporal variability of blood-oxygenation-level-dependent (BOLD) signals, an indicator of the brain’s flexibility and efficiency and if this change is associated with pain improvement. In a within-subjects cross-over design, 12 female FM patients underwent sham and active tDCS on 5 consecutive days, respectively. Each session was performed with an anode placed on the left M1 and a cathode on the contralateral supraorbital region. The subjects also participated in resting-state functional magnetic resonance imaging (fMRI) at baseline and after sham and active tDCS. We compared the BOLD signal variability (SDBOLD), defined as the standard deviation of the BOLD time-series, between the tDCS conditions. Baseline SDBOLD was compared to 15 healthy female controls. At baseline, FM patients showed reduced SDBOLD in the ventromedial prefrontal cortex (vmPFC), lateral PFC, and anterior insula and increased SDBOLD in the posterior insula compared to healthy controls. After active tDCS, compared to sham, we found an increased SDBOLD in the left rostral anterior cingulate cortex (rACC), lateral PFC, and thalamus. After sham tDCS, compared to baseline, we found a decreased SDBOLD in the dorsomedial PFC and posterior cingulate cortex/precuneus. Interestingly, after active tDCS compared to sham, pain reduction was correlated with an increased SDBOLD in the rACC/vmPFC but with a decreased SDBOLD in the posterior insula. Our findings suggest that M1-tDCS might revert temporal variability of fMRI signals in the rACC/vmPFC and posterior insula linked to FM pain. Changes in neural variability would be part of the mechanisms underlying repetitive M1-tDCS analgesia in FM.
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DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
5.9
作者：
Fitzcharles, Mary-Ann;Ste-Marie, Peter A.;Shir, Yoram
通讯作者：
Shir, Yoram
影响因子：
4
作者：
Bolognini, Nadia;Spandri, Viviana;Maravita, Angelo
通讯作者：
Maravita, Angelo
影响因子：
16.2
作者：
Eippert, Falk;Bingel, Ulrike;Buechel, Christian
通讯作者：
Buechel, Christian
影响因子：
4.9
作者：
Cummiford, Chelsea M.;Nascimento, Thiago D.;DaSilva, Alexandre F.
通讯作者：
DaSilva, Alexandre F.