Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming
Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming
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周围神经驻留巨噬细胞是具有组织特异性编程的小胶质细胞样细胞
DOI：
10.1101/2019.12.19.883546
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
G. Randolph
中科院分区：
文献类型：
--
作者：
Peter L. Wang;A. Yim;Kiwook Kim;D. Avey;R. Czepielewski;M. Colonna;J. Milbrandt;G. Randolph
尽管小胶质细胞被认为是中枢神经系统（CNS）发育和功能的基本参与者，但对外周神经系统（PNS）的巨噬细胞知之甚少。在这里，我们表明，自我维持的PNS巨噬细胞与CNS小胶质细胞共享独特的功能。通过比较神经和常规组织驻留巨噬细胞的基因表达，我们确定了在神经驻留巨噬细胞之间共享的转录本，以及选择性地富集在PNS巨噬细胞中。值得注意的是，PNS巨噬细胞组成型表达基因先前被确定为在衰老或神经变性过程中被激活的小胶质细胞上调。几个小胶质细胞激活相关和PNS巨噬细胞富集基因也表达在脊髓小胶质细胞在稳态。虽然PNS巨噬细胞从胚胎和造血前体细胞中产生，但其激活相关基因的表达并不因个体发育而异。总的来说，这些数据揭示了神经驻留巨噬细胞之间的共享和独特的功能，并强调了神经环境对塑造PNS巨噬细胞身份的作用。
Whereas microglia are recognized as fundamental players in central nervous system (CNS) development and function, much less is known about macrophages of the peripheral nervous system (PNS). Here we show that self-maintaining PNS macrophages share unique features with CNS microglia. By comparing gene expression across neural and conventional tissue-resident macrophages, we identified transcripts that were shared among neural resident macrophages as well as selectively enriched in PNS macrophages. Remarkably, PNS macrophages constitutively expressed genes previously identified to be upregulated by activated microglia during aging or neurodegeneration. Several microglial activation-associated and PNS macrophage-enriched genes were also expressed in spinal cord microglia at steady state. While PNS macrophages arose from both embryonic and hematopoietic precursors, their expression of activation-associated genes did not differ by ontogeny. Collectively, these data uncover shared and unique features between neural resident macrophages and emphasize the role of nerve environment for shaping PNS macrophage identity.
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影响因子：
30.5
作者：
Goldmann T;Wieghofer P;Jordão MJ;Prutek F;Hagemeyer N;Frenzel K;Amann L;Staszewski O;Kierdorf K;Krueger M;Locatelli G;Hochgerner H;Zeiser R;Epelman S;Geissmann F;Priller J;Rossi FM;Bechmann I;Kerschensteiner M;Linnarsson S;Jung S;Prinz M
通讯作者：
Prinz M
影响因子：
64.8
作者：
Gomez Perdiguero E;Klapproth K;Schulz C;Busch K;Azzoni E;Crozet L;Garner H;Trouillet C;de Bruijn MF;Geissmann F;Rodewald HR
通讯作者：
Rodewald HR
影响因子：
8.8
作者：
Friedman, Brad A.;Srinivasan, Karpagam;Hansen, David V.
通讯作者：
Hansen, David V.
影响因子：
19
作者：
Frost JL;Schafer DP
通讯作者：
Schafer DP
影响因子：
32.4
作者：
Zhu Y;Herndon JM;Sojka DK;Kim KW;Knolhoff BL;Zuo C;Cullinan DR;Luo J;Bearden AR;Lavine KJ;Yokoyama WM;Hawkins WG;Fields RC;Randolph GJ;DeNardo DG
通讯作者：
DeNardo DG