Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion
Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion
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Foxp2 调节可能与声音行为和双足运动相关的解剖特征
DOI：
10.1073/pnas.1721820115
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发表时间：
2018-08
影响因子：
11.1
通讯作者：
Liu Quansheng
中科院分区：
文献类型：
--
作者：
Xu Shuqin;Liu Pei;Chen Yuanxing;Chen Yi;Zhang Wei;Zhao Haixia;Cao Yiwei;Wang Fuhua;Jiang Nana;Lin Shifeng;Li Baojie;Zhang Zhenlin;Wei Zhanying;Fan Ying;Jin Yunyun;He Lin;Zhou Rujiang;Dekker Joseph D;Tucker Haley O;Fisher Simon E;Yao Zhengju;Liu Quansheng
意义语言和两足行走是人类进化过程中出现的行为的关键方面。FOXP2是一种与人类言语和语言障碍有关的基因，被认为有助于语言进化。在这里，通过敲除小鼠Foxp2的研究，我们表明，这个基因不仅是重要的参与发声行为的神经回路，它也有助于调节相关的解剖基板。我们还表明，Foxp2影响骨骼功能，可能是相关的双足运动。我们的研究结果提高了FOXP2可能对衍生人类特征的解剖学特征很重要的可能性，包括言语和两足动物。基本的人类特征，如语言和两足行走，与颅面成形和骨骼重塑中的一系列解剖学适应有关。然而，目前尚不清楚这些形态特征是如何在人类进化过程中出现的。FOXP2是一种脑表达的转录因子，与涉及言语失用症和语言障碍的罕见疾病有关。对其进化历史的分析表明，这种基因可能有助于熟练口语的出现。在本研究中，通过分析特异性敲除小鼠，我们确定了Foxp2在颅骨成形和骨重建中的作用。选择性消融软骨中的Foxp2以类似于全球Foxp2突变体的方式破坏了幼犬的发声，这可能是由于对颅面形态发生的多效性作用。我们的研究结果还表明，Foxp2有助于调节后肢的力量和长度以及关节软骨和椎间盘的维持，这些都是易于适应双足运动的解剖学特征。鉴于Foxp2在大脑回路中的已知作用对运动技能和口语非常重要，我们认为该基因可能有助于与语音和双足运动相关的神经和解剖学适应的共同进化。
Significance Speech and bipedalism are key aspects of behavior that emerged during human evolution. FOXP2, a gene implicated in a human speech and language disorder, has been suggested to contribute to language evolution. Here, through knockout studies of mouse Foxp2, we show that this gene is not only important for neural circuits involved in vocal behaviors, it also helps regulate relevant anatomical substrates. We additionally demonstrate that Foxp2 influences skeletal features that may be relevant for bipedal locomotion. Our findings raise the possibility that FOXP2 might be important for anatomical features contributing to derived human traits, including speech and bipedalism. Fundamental human traits, such as language and bipedalism, are associated with a range of anatomical adaptations in craniofacial shaping and skeletal remodeling. However, it is unclear how such morphological features arose during hominin evolution. FOXP2 is a brain-expressed transcription factor implicated in a rare disorder involving speech apraxia and language impairments. Analysis of its evolutionary history suggests that this gene may have contributed to the emergence of proficient spoken language. In the present study, through analyses of skeleton-specific knockout mice, we identified roles of Foxp2 in skull shaping and bone remodeling. Selective ablation of Foxp2 in cartilage disrupted pup vocalizations in a similar way to that of global Foxp2 mutants, which may be due to pleiotropic effects on craniofacial morphogenesis. Our findings also indicate that Foxp2 helps to regulate strength and length of hind limbs and maintenance of joint cartilage and intervertebral discs, which are all anatomical features that are susceptible to adaptations for bipedal locomotion. In light of the known roles of Foxp2 in brain circuits that are important for motor skills and spoken language, we suggest that this gene may have been well placed to contribute to coevolution of neural and anatomical adaptations related to speech and bipedal locomotion.
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影响因子：
9.8
作者：
Feuk, Lars;Kalervo, Aino;Hannula-Jouppi, Katariina
通讯作者：
Hannula-Jouppi, Katariina
影响因子：
9.2
作者：
Groszer, Matthias;Keays, David A.;Deacon, Robert M. J.;de Bono, Joseph P.;Prasad-Mulcare, Shweta;Gaub, Simone;Baum, Muriel G.;French, Catherine A.;Nicod, Jrme;Coventry, Julie A.;Enard, Wolfgang;Fray, Martin;Brown, Steve D. M.;Nolan, Patrick M.;Paeaebo, Svante;Channon, Keith M.;Costa, Rui M.;Eilers, Jens;Ehret, Guenter;Nicholas, J.;Rawlins, P.;Fisher, Simon E.
通讯作者：
Fisher, Simon E.
影响因子：
16.6
作者：
Elemans CP;Rasmussen JH;Herbst CT;Düring DN;Zollinger SA;Brumm H;Srivastava K;Svane N;Ding M;Larsen ON;Sober SJ;Švec JG
通讯作者：
Švec JG
影响因子：
25
作者：
Chen, Yi-Chuan;Kuo, Hsiao-Ying;Bornschein, Ulrich;Takahashi, Hiroshi;Chen, Shih-Yun;Lu, Kuan-Ming;Yang, Hao-Yu;Chen, Gui-May;Lin, Jing-Ruei;Lee, Yi-Hsin;Chou, Yun-Chia;Cheng, Sin-Jhong;Chien, Cheng-Ting;Enard, Wolfgang;Hevers, Wulf;Paeaebo, Svante;Graybiel, Ann M.;Liu, Fu-Chin
通讯作者：
Liu, Fu-Chin
影响因子：
2.6
作者：
Schulze K;Vargha-Khadem F;Mishkin M
通讯作者：
Mishkin M