Cancer incidence in a sample of Maryland residents with serious mental illness.
Cancer incidence in a sample of Maryland residents with serious mental illness.
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DOI：
10.1176/appi.ps.201100169
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Daumit GL
中科院分区：
文献类型：
--
作者：
McGinty EE;Zhang Y;Guallar E;Ford DE;Steinwachs D;Dixon LB;Keating NL;Daumit GL
与没有严重精神疾病的人相比，患有严重精神疾病的人死亡率更高，许多医疗条件的负担也更高，但严重精神疾病人群的癌症风险是不确定的。以社区为基础的成人精神分裂症或双相情感障碍的癌症发病率按种族、性别和癌症部位进行了检查。我们计算了总癌症和特定部位癌症的标准化发病率，比较了从1994年到2004年的3317名马里兰州医疗补助成年精神分裂症或双相情感障碍受益人与美国人口。患有精神分裂症或双相情感障碍的成年人的总癌症发病率是美国人口的2.6倍。患有严重精神疾病的人患肺癌和支气管癌的风险最高。患有严重精神疾病的非裔美国人与白人医疗补助受益人在风险上没有差异。这些发现表明，患有精神分裂症或双相情感障碍的成年人患癌症的风险更高。临床医生应促进适当的癌症筛查，并努力减少严重精神疾病患者中可改变的风险因素，如吸烟。
Persons with serious mental illness have an increased mortality rate and a higher burden of many medical conditions compared to those without serious mental illness, but cancer risk in the serious mental illness population is uncertain. Cancer incidence in a community-based cohort of adults with schizophrenia or bipolar disorder was examined by race, sex, and cancer site. We calculated standardized incidence ratios of total and site-specific cancers comparing a cohort of 3317 Maryland Medicaid adult beneficiaries with schizophrenia or bipolar disorder followed from 1994 through 2004 to the U.S. population. Total cancer incidence for adults with schizophrenia or bipolar disorder was 2.6 times higher than in the U.S. population. Elevated risk in persons with serious mental illness was greatest for cancer of the lung and bronchus. No differences in risk were found for African American versus white Medicaid beneficiaries with serious mental illness. These findings suggest heightened risk for cancer among adults with schizophrenia or bipolar disorder. Clinicians should promote appropriate cancer screening and work to reduce modifiable risk factors, such as smoking, among persons with serious mental illness.
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