Ventilatory stability to transient CO2 disturbances in hyperoxia and normoxia in awake humans.
Ventilatory stability to transient CO2 disturbances in hyperoxia and normoxia in awake humans.
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清醒人类高氧和正常氧条件下短暂二氧化碳扰动的通气稳定性。
DOI：
10.1152/jappl.1997.83.2.466
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bruce,EN
中科院分区：
文献类型：
--
作者：
Lai,J;Bruce,EN
Lai, Jie, and Eugene N. Bruce.Ventilatory stability to transient CO2disturbances in hyperoxia and normoxia in awake humans.J. Appl. Physiol.83(2): 466–476, 1997.—Modarreszadeh and Bruce (J. Appl. Physiol. 76: 2765–2775, 1994) proposed that continuous random disturbances in arterialare more likely to elicit ventilatory oscillation patterns that mimic periodic breathing in normoxia than in hyperoxia. To test this hypothesis experimentally, in nine awake humans we applied pseudorandom binary inspired CO2fraction stimulation in normoxia and hyperoxia to derive the closed-loop and open-loop ventilatory responses to a brief CO2disturbance in terms of impulse responses and transfer functions. The closed-loop impulse response has a significantly higher peak value [0.143 ± 0.071 vs. 0.079 ± 0.034 (SD) l ⋅ min−1⋅ 0.01 l CO2−1,P= 0.014] and a significantly shorter 50% response duration (42.7 ± 13.3 vs. 72.3 ± 27.6 s,P= 0.020) in normoxia than in hyperoxia. Therefore, the ventilatory responses to transient CO2disturbances are less damped (but generally not oscillatory) in normoxia than in hyperoxia. For the closed-loop transfer function, the gain in normoxia increased significantly (P< 0.0005), while phase delay decreased significantly (P< 0.0005). The gain increased by 108.5, 186.0, and 240.6%, while phase delay decreased by 26.0, 18.1, and 17.3%, at 0.01, 0.03, and 0.05 Hz, respectively. Changes in the same direction were found for the open-loop system. Generally, an oscillatory ventilatory response to a small transient CO2disturbance is unlikely during wakefulness. However, changes in parameters that lead to additional increases in chemoreflex loop gain are more likely to initiate oscillations in normoxia than in hyperoxia.
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影响因子：
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作者：
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DOI：
10.1007/978-1-4757-9847-0_24
发表时间：
1992
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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CHERNIACK, NS
DOI：
10.1016/0034-5687(92)90031-q
发表时间：
1992-04-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
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作者：
CLEMENT, ID;BASCOM, DA;ROBBINS, PA
通讯作者：
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DOI：
10.1113/jphysiol.1984.sp015212
发表时间：
1984
期刊：
The Journal of Physiology
影响因子：
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作者：
P. Robbins
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P. Robbins