A motive for killing: effector functions of regulated lytic cell death.
A motive for killing: effector functions of regulated lytic cell death.
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DOI：
10.1038/icb.2016.113
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发表时间：
2017-03
影响因子：
4
通讯作者：
Croker BA
中科院分区：
文献类型：
--
作者：
Bliss-Moreau M;Chen AA;D'Cruz AA;Croker BA
病原体识别激活的免疫反应有多种形式。免疫细胞的增殖、分化和募集以及炎性细胞因子和趋化因子的产生是终身免疫的核心。细胞死亡在解决先天性和适应性免疫应答中起着关键作用。它还协调细胞内在效应子功能以限制感染。坏死被正式认为是细胞死亡的被动形式或病原体毒力因子表达的结果，并且坏死组织通常与感染相关。然而，现在有新的证据表明，坏死的调节形式，如焦亡和坏死，驱动炎症和塑造免疫反应的作用。
Immunological responses activated by pathogen recognition come in many guises. The proliferation, differentiation and recruitment of immune cells, and the production of inflammatory cytokines and chemokines are central to lifelong immunity. Cell death serves as a key function in the resolution of innate and adaptive immune responses. It also coordinates cell-intrinsic effector functions to restrict infection. Necrosis was formally considered a passive form of cell death or a consequence of pathogen virulence factor expression, and necrotic tissue is frequently associated with infection. However, there is now emerging evidence that points to a role for regulated forms of necrosis, such as pyroptosis and necroptosis, driving inflammation and shaping the immune response.
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DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
8.8
作者：
Dondelinger, Yves;Declercq, Wim;Vandenabeele, Peter
通讯作者：
Vandenabeele, Peter
影响因子：
5.4
作者：
Desai, Jyaysi;Kumar, Santhosh V.;Anders, Hans-Joachim
通讯作者：
Anders, Hans-Joachim
影响因子：
3.6
作者：
Brennan, MA;Cookson, BT
通讯作者：
Cookson, BT
DOI：
10.1126/science.1240988
发表时间：
2013-09-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hagar JA;Powell DA;Aachoui Y;Ernst RK;Miao EA
通讯作者：
Miao EA