The Emerging Role of Protein Phosphatase in Regeneration.
The Emerging Role of Protein Phosphatase in Regeneration.
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DOI：
10.3390/life13051216
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发表时间：
2023-05-19
期刊：
影响因子：
3.2
通讯作者：
Su, Ying
中科院分区：
文献类型：
--
作者：
Zhang, Meiling;Liu, Chenglin;Zhao, Long;Zhang, Xuejiao;Su, Ying
维持正常的细胞行为对生物体的生存至关重要。控制细胞行为的主要机制之一是蛋白质磷酸化。蛋白质磷酸化过程在蛋白激酶和蛋白磷酸酶的调控下是可逆的。激酶在许多细胞过程中的重要性已被充分认识。近年来，蛋白磷酸酶也被证明在各种细胞过程中发挥积极而特异的作用，因此受到越来越多的研究者的关注。在动物界，再生经常发生，以取代或修复受损或缺失的组织。新出现的证据表明，蛋白磷酸酶对器官再生至关重要。本文简要介绍了蛋白磷酸酶的分类及其在几种典型发育过程中的作用，并通过对蛋白磷酸酶在脊椎动物肝脏、骨骼、神经元和心脏再生中的作用及其机制的最新研究，着重阐述了蛋白磷酸酶在器官再生中的重要作用。
Maintaining normal cellular behavior is essential for the survival of organisms. One of the main mechanisms to control cellular behavior is protein phosphorylation. The process of protein phosphorylation is reversible under the regulation of protein kinases and protein phosphatases. The importance of kinases in numerous cellular processes has been well recognized. In recent years, protein phosphatases have also been demonstrated to function actively and specifically in various cellular processes and thus have gained more and more attention from researchers. In the animal kingdom, regeneration frequently occurs to replace or repair damaged or missing tissues. Emerging evidence has revealed that protein phosphatases are crucial for organ regeneration. In this review, after providing a brief overview of the classification of protein phosphatases and their functions in several representative developmental processes, we highlight the critical roles that protein phosphatases play in organ regeneration by summarizing the most recent research on the function and underlying mechanism of protein phosphatase in the regeneration of the liver, bone, neuron, and heart in vertebrates.
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DOI：
10.1083/jcb.200705035
发表时间：
2007-09-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Wyatt L;Wadham C;Crocker LA;Lardelli M;Khew-Goodall Y
通讯作者：
Khew-Goodall Y
影响因子：
7.3
作者：
Avruch, Joseph;Zhou, Dawang;Fitamant, Julien;Bardeesy, Nabeel;Mou, Fan;Barrufet, Laura Regue
通讯作者：
Barrufet, Laura Regue
Pr72 的缺失会导致斑马鱼心脏发育缺陷。
影响因子：
3.7
作者：
Song G;Han M;Li Z;Gan X;Chen X;Yang J;Dong S;Yan M;Wan J;Wang Y;Huang Z;Yin Z;Zheng F
通讯作者：
Zheng F
影响因子：
14.8
作者：
Brauer BL;Wiredu K;Mitchell S;Moorhead GB;Gerber SA;Kettenbach AN
通讯作者：
Kettenbach AN
影响因子：
37.8
作者：
Benjamin, Emelia J.;Virani, Salim S.;Muntner, Paul
通讯作者：
Muntner, Paul