Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations.
Gut Microbiota Interplay With COVID-19 Reveals Links to Host Lipid Metabolism Among Middle Eastern Populations.
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肠道微生物群与 COVID-19 的相互作用揭示了中东人群宿主脂质代谢的联系。
DOI：
10.3389/fmicb.2021.761067
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发表时间：
2021
影响因子：
5.2
通讯作者：
Alsafar HS
中科院分区：
文献类型：
--
作者：
Al Bataineh MT;Henschel A;Mousa M;Daou M;Waasia F;Kannout H;Khalili M;Kayasseh MA;Alkhajeh A;Uddin M;Alkaabi N;Tay GK;Feng SF;Yousef AF;Alsafar HS
胃肠道微生物组的组成变化、严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的易感性和严重程度以及宿主功能之间的相互作用是复杂的，尚未完全了解。这项研究对143名受试者进行了基于16 S rRNA基因的微生物谱分析。我们观察到与未感染对照组相比，SARS-CoV-2感染组肠道微生物群的结构和组成发生了变化。SARS-CoV-2感染个体的肠道微生物群组成显示抗炎细菌如粪杆菌（p值= 1.72 × 10-6）和拟杆菌（p值= 5.67 × 10-8）增加。我们还发现，与对照组相比，SARS-CoV-2感染组中高度有益的丁酸生产者，如Anaerostipes（p值= 1.75 × 10-230），毛螺菌科（p值= 7.14 × 10-65）和Blautia（p值= 9.22 × 10-18）的相对丰度更高。此外，通过重建未观察状态（PICRUSt）功能预测分析的16 S rRNA基因丰度数据的社区的系统发育调查显示，丰富的代谢途径，如脂质，氨基酸，碳水化合物，和异源生物质代谢，在两组之间的比较有很大的差异。我们发现在SARS-CoV-2感染组中亚油酸、醚脂、甘油脂和甘油磷脂代谢的富集，表明与SARS-CoV-2在宿主细胞中的进入和复制有关。我们估计主要贡献属的四个途径是副拟杆菌，链球菌，Dorea，和Blautia，分别。确定的差异提供了一个新的见解，以丰富我们对SARS-CoV-2相关的肠道微生物群变化，其代谢能力以及与COVID-19疾病严重程度相关的潜在筛选生物标志物的理解。
The interplay between the compositional changes in the gastrointestinal microbiome, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and severity, and host functions is complex and yet to be fully understood. This study performed 16S rRNA gene-based microbial profiling of 143 subjects. We observed structural and compositional alterations in the gut microbiota of the SARS-CoV-2-infected group in comparison to non-infected controls. The gut microbiota composition of the SARS-CoV-2-infected individuals showed an increase in anti-inflammatory bacteria such as Faecalibacterium (p-value = 1.72 × 10–6) and Bacteroides (p-value = 5.67 × 10–8). We also revealed a higher relative abundance of the highly beneficial butyrate producers such as Anaerostipes (p-value = 1.75 × 10–230), Lachnospiraceae (p-value = 7.14 × 10–65), and Blautia (p-value = 9.22 × 10–18) in the SARS-CoV-2-infected group in comparison to the control group. Moreover, phylogenetic investigation of communities by reconstructing unobserved state (PICRUSt) functional prediction analysis of the 16S rRNA gene abundance data showed substantial differences in the enrichment of metabolic pathways such as lipid, amino acid, carbohydrate, and xenobiotic metabolism, in comparison between both groups. We discovered an enrichment of linoleic acid, ether lipid, glycerolipid, and glycerophospholipid metabolism in the SARS-CoV-2-infected group, suggesting a link to SARS-CoV-2 entry and replication in host cells. We estimate the major contributing genera to the four pathways to be Parabacteroides, Streptococcus, Dorea, and Blautia, respectively. The identified differences provide a new insight to enrich our understanding of SARS-CoV-2-related changes in gut microbiota, their metabolic capabilities, and potential screening biomarkers linked to COVID-19 disease severity.
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
影响因子：
5.2
作者：
Garcia-Mantrana I;Selma-Royo M;Alcantara C;Collado MC
通讯作者：
Collado MC
COVID-19对受感染患者的细胞色素P450介导的药物代谢和处置的潜在影响。
DOI：
10.1007/s13318-020-00668-8
发表时间：
2021-03
影响因子：
1.9
作者：
Deb S;Arrighi S
通讯作者：
Arrighi S
DOI：
10.1016/j.jaci.2021.02.001
发表时间：
2021-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Rosas-Salazar C;Kimura KS;Shilts MH;Strickland BA;Freeman MH;Wessinger BC;Gupta V;Brown HM;Rajagopala SV;Turner JH;Das SR
通讯作者：
Das SR
影响因子：
8
作者：
Iljazovic A;Roy U;Gálvez EJC;Lesker TR;Zhao B;Gronow A;Amend L;Will SE;Hofmann JD;Pils MC;Schmidt-Hohagen K;Neumann-Schaal M;Strowig T
通讯作者：
Strowig T