Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity.
Supramolecular Organization As a Factor of Ribonuclease Cytotoxicity.
复制标题
DOI：
10.32607/actanaturae.11000
复制
发表时间：
2020-07
期刊：
影响因子：
2
通讯作者：
Ilinskaya ON
中科院分区：
文献类型：
--
作者：
Dudkina EV;Ulyanova VV;Ilinskaya ON
用于消除肿瘤细胞的方法之一是直接破坏/修饰它们的RNA分子。在这方面，核糖核酸酶（RNases）具有很大程度上尚未开发的治疗潜力。人们认为，分泌的rna酶的生物学作用，即其抗肿瘤和抗病毒特性，源于其催化活性。然而，最近的一些研究挑战了rna酶对癌细胞选择性细胞毒性表现的活性完全是酶的概念。在这篇综述中，我们分析了现有的关于分泌的rna酶的细胞毒性作用的数据，这些数据与它们的催化活性无关，我们提供的证据表明，在rna酶的选择性凋亡诱导作用中，最重要的因素是这些酶的结构组织，这决定了它们如何与细胞成分相互作用。关于rnase与癌细胞之间非催化相互作用在选择性细胞毒性表现中的优势作用的新观点将有助于基于rnase的抗肿瘤药物的开发。
One of the approaches used to eliminate tumor cells is directed destruction/modification of their RNA molecules. In this regard, ribonucleases (RNases) possess a therapeutic potential that remains largely unexplored. It is believed that the biological effects of secreted RNases, namely their antitumor and antiviral properties, derive from their catalytic activity. However, a number of recent studies have challenged the notion that the activity of RNases in the manifestation of selective cytotoxicity towards cancer cells is exclusively an enzymatic one. In this review, we have analyzed available data on the cytotoxic effects of secreted RNases, which are not associated with their catalytic activity, and we have provided evidence that the most important factor in the selective apoptosis-inducing action of RNases is the structural organization of these enzymes, which determines how they interact with cell components. The new idea on the preponderant role of non-catalytic interactions between RNases and cancer cells in the manifestation of selective cytotoxicity will contribute to the development of antitumor RNase-based drugs.
登录
查看更多内容
影响因子：
4.1
作者：
Bracale, A;Spalletti-Cernia, D;D'Alessio, G
通讯作者：
D'Alessio, G
影响因子：
3.7
作者：
Dudkina E;Kayumov A;Ulyanova V;Ilinskaya O
通讯作者：
Ilinskaya O
影响因子：
3.5
作者：
APHANASENKO, GA;DUDKIN, SM;SEVERIN, ES
通讯作者：
SEVERIN, ES
影响因子：
--
作者：
Alford, Spencer C.;Pearson, Joel D.;Howard, Perry L.
通讯作者：
Howard, Perry L.
影响因子：
3.5
作者：
Furia, Adriana;Moscato, Marco;D'Alessio, Giuseppe
通讯作者：
D'Alessio, Giuseppe