Solid Organ Bioprinting: Strategies to Achieve Organ Function.
Solid Organ Bioprinting: Strategies to Achieve Organ Function.
复制标题
固体器官生物打印：实现器官功能的策略。
DOI：
10.1021/acs.chemrev.0c00145
复制
发表时间：
2020-10-14
期刊：
影响因子：
62.1
通讯作者：
Atala A
中科院分区：
文献类型：
--
作者：
Jorgensen AM;Yoo JJ;Atala A
组织工程领域在过去十年中取得了进步，但对人类健康的最大影响应该是随着工程实体器官向临床的过渡。患有实体器官疾病的患者数量继续增加，美国全国候补名单上的患者超过10万人，美国每年约有73万人死于终末期器官疾病。虽然扁平、管状和中空的非管状工程化器官已经被植入患者体内，但在体外形成可翻译规模的全功能固体器官还没有实现。因此，一个主要的目标是生物工程复杂的，用于移植的固体器官，由患者特定的细胞组成。在无数尝试设计实体器官的方法中，3D生物打印提供了无与伦比的潜力。这篇综述强调了结构的复杂性，必须在纳米、微观和中观结构尺度上进行工程才能使器官功能发挥作用。我们展示了在生物打印具有复杂血管网络和功能微结构的固体器官方面的关键进展，使这一进展成为可能的生物材料科学的进展，该领域尚未克服的监管障碍，以及使我们更接近工程固体器官前景的尖端技术。
The field of tissue engineering has advanced over the last decade, but the largest impact on human health should be achieved with the transition of engineered solid organs to the clinic. The number of patients suffering from solid organ disease continues to increase, with over 100,000 patients on the US national waitlist and approximately 730,000 deaths in the United States resulting from end-stage organ disease annually. While flat, tubular, and hollow non-tubular engineered organs have already been implanted in patients, in vitro formation of a fully functional solid organ at a translatable scale has not yet been achieved. Thus, one major goal is to bioengineer complex, solid organs for transplantation, composed of patient-specific cells. Among the myriad of approaches attempted to engineer solid organs, 3D bioprinting offers unmatched potential. This review highlights the structural complexity which must be engineered at nano-, micro-, and mesostructural scales to enable organ function. We showcase key advances in bioprinting solid organs with complex vascular networks and functioning microstructures, advances in biomaterials science that have enabled this progress, the regulatory hurdles the field has yet to overcome, and cutting edge technologies that bring us closer to the promise of engineered solid organs.
登录
查看更多内容
影响因子：
--
作者：
Blaeser A;Duarte Campos DF;Weber M;Neuss S;Theek B;Fischer H;Jahnen-Dechent W
通讯作者：
Jahnen-Dechent W
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
6.2
作者：
Blomeier, Herman;Zhang, Xiaomin;Lowe, William L., Jr.
通讯作者：
Lowe, William L., Jr.
影响因子：
10
作者：
Ali, Mohamed;Kumar, Anil P. R.;Lee, Sang Jin
通讯作者：
Lee, Sang Jin
影响因子：
9
作者：
Campos, Daniela F. Duarte;Blaeser, Andreas;Fischer, Horst
通讯作者：
Fischer, Horst