Autophagy in cardiovascular diseases: role of noncoding RNAs.
Autophagy in cardiovascular diseases: role of noncoding RNAs.
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自噬在心血管疾病中的作用：非编码RNA的作用
DOI：
10.1016/j.omtn.2020.10.039
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发表时间：
2021-03-05
期刊：
影响因子：
--
通讯作者：
Shao K
中科院分区：
文献类型：
--
作者：
Gao J;Chen X;Shan C;Wang Y;Li P;Shao K
心血管疾病(CVD)仍然是世界上主要的死亡原因。心肌细胞自噬有助于维持心脏的正常新陈代谢和功能。重要的是，越来越多的证据表明，自噬在CVD病理中起着双重作用。在生理条件下，适度的自噬通过降解和回收受损的细胞器和蛋白质来维持细胞代谢平衡，并促进心肌存活，但过度或不足的自噬同样有害，并有助于疾病的进展。非编码RNAs(NcRNAs)是一类从基因组转录而来的RNA，但大多数ncRNAs并不编码功能蛋白。近年来，越来越多的ncRNAs被发现，它们在生物体的生理和病理过程以及自噬过程中发挥着重要的调节作用。因此，确定ncRNA调节的自噬在心血管疾病中起到保护作用还是促进其进展可以帮助我们开发ncRNA作为自噬相关心血管疾病的治疗靶点。本文简要综述了几种重要的ncRNAs，包括microRNAs(MiRNAs)、Long ncRNAs(LncRNAs)和CircRNAs(CircRNAs)在各种心血管疾病自噬中的调节作用，以期为心血管疾病的病因和发病机制提供理论依据，并开发治疗心血管疾病的新疗法。心血管疾病(CVD)仍然是世界上主要的死亡原因。越来越多的证据表明，ncRNAs和自噬在CVD的病理过程中起着关键作用。确定ncRNA调节的自噬在心血管疾病中是否起到保护作用或促进其进展可以帮助我们开发ncRNA作为自噬相关心血管疾病的治疗靶点。
Cardiovascular diseases (CVDs) remain the world’s leading cause of death. Cardiomyocyte autophagy helps maintain normal metabolism and functioning of the heart. Importantly, mounting evidence has revealed that autophagy plays a dual role in CVD pathology. Under physiological conditions, moderate autophagy maintains cell metabolic balance by degrading and recycling damaged organelles and proteins, and it promotes myocardial survival, but excessive or insufficient autophagy is equally deleterious and contributes to disease progression. Noncoding RNAs (ncRNAs) are a class of RNAs transcribed from the genome, but most ncRNAs do not code for functional proteins. In recent years, increasingly, various ncRNAs have been identified, and they play important regulatory roles in the physiological and pathological processes of organisms, as well as in autophagy. Thus, determining whether ncRNA-regulated autophagy plays a protective role in CVDs or promotes their progression can help us to develop ncRNAs as therapeutic targets in autophagy-related CVDs. In this review, we briefly summarize the regulatory roles of several important ncRNAs, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the autophagy of various CVDs to provide a theoretical basis for the etiology and pathogenesis of CVDs and develop novel therapies to treat CVDs. Cardiovascular diseases (CVDs) remain the world’s leading cause of death. Mounting evidence has revealed that ncRNAs and autophagy play critical roles in CVD pathology. Determining whether ncRNA-regulated autophagy plays a protective role in CVDs or promotes their progression can help us to develop ncRNAs as therapeutic targets in autophagy-related CVDs.
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DOI：
10.1007/s00018-017-2688-5
发表时间：
2018-03
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Holdt LM;Kohlmaier A;Teupser D
通讯作者：
Teupser D
MicroRNA-21 通过 Akt/mTOR 通路抑制 H9c2 细胞中的过度自噬，从而防止心脏缺氧/复氧损伤
影响因子：
5.3
作者：
Huang Z;Wu S;Kong F;Cai X;Ye B;Shan P;Huang W
通讯作者：
Huang W
影响因子：
12.4
作者：
Bo, L.;Su-Ling, D.;Pei-Feng, L.
通讯作者：
Pei-Feng, L.
影响因子：
4.8
作者：
Das, Anindita;Durrant, David;Kukreja, Rakesh C.
通讯作者：
Kukreja, Rakesh C.
影响因子：
5.6
作者：
Gao J;Xu W;Wang J;Wang K;Li P
通讯作者：
Li P