Induced regeneration--the progress and promise of direct reprogramming for heart repair.
Induced regeneration--the progress and promise of direct reprogramming for heart repair.
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Regeneration of cardiac tissue has the potential to transform cardiovascular medicine. Recent advances in stem cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools to advance this goal. In this Review we examine key developments in the generation of new cardiomyocytes in vitro as well as the exciting progress that has been made toward in vivo reprogramming of cardiac tissue. We also address controversies and hurdles that challenge the field.
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影响因子:
23.9
作者:
Burridge, Paul W.;Keller, Gordon;Gold, Joseph D.;Wu, Joseph C.
通讯作者:
Wu, Joseph C.
影响因子:
3.1
作者:
Chiu, Loraine L. Y.;Iyer, Rohin K.;Radisic, Milica
通讯作者:
Radisic, Milica
DOI:
10.1073/pnas.0711961105
发表时间:
2008-04-22
影响因子:
11.1
作者:
Feng, Ru;Desbordes, Sabrina C.;Graf, Thomas
通讯作者:
Graf, Thomas
影响因子:
23.9
作者:
Bondue, Antoine;Lapouge, Gaelle;Blanpain, Cedric
通讯作者:
Blanpain, Cedric
影响因子:
5.3
作者:
EVANS, SM;TAI, LJ;CHIEN, KR
通讯作者:
CHIEN, KR