Subspecific origin and haplotype diversity in the laboratory mouse.
Subspecific origin and haplotype diversity in the laboratory mouse.
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作者：
在这里，我们提供了第一个全基因组，最现存的实验室小鼠近交系基因组的系统发育起源的高分辨率地图。我们的分析是基于野生捕获的小鼠从小家鼠的三个亚种的基因型。我们证明，经典的实验室菌株是来自少数花式小鼠有限的单倍型多样性。它们的基因组绝大多数是M。M.原产于日本，其余大部分是日本血统。我们根据来自花式小鼠的血统身份生成了全基因组单倍型图谱，并证明经典近交系具有有限的非随机分布的遗传多样性。相比之下，野生来源的实验室菌株代表了M.肌肉在这些菌株中，亚种间的渐渗是普遍的，实验室原种的污染在这一过程中发挥了作用。亚种起源，单倍型多样性和身份的下降地图可以可视化和在线搜索。
Here we provide the first genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild caught mice from three subspecies of Mus musculus. We demonstrate that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly M. m. domesticus in origin and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and demonstrate that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains and contamination by laboratory stocks has played role in this process. The subspecific origin, haplotype diversity and identity by descent maps can be visualized and searched online.
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影响因子：
2.5
作者：
NAGAMINE, CM;NISHIOKA, Y;LAU, YFC
通讯作者：
LAU, YFC
影响因子：
2.5
作者：
TUCKER, PK;LEE, BK;EICHER, EM
通讯作者：
EICHER, EM
影响因子：
4.5
作者：
White MA;Ané C;Dewey CN;Larget BR;Payseur BA
通讯作者：
Payseur BA
影响因子：
56.9
作者：
Mihola, Ondrej;Trachtulec, Zdenek;Forejt, Jiri
通讯作者：
Forejt, Jiri
影响因子：
7
作者：
Ideraabdullah, FY;de la Casa-Esperón, E;de Villena, FPM
通讯作者：
de Villena, FPM