Changes in cell and tissue organization in cancer of the breast and colon.
Changes in cell and tissue organization in cancer of the breast and colon.
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DOI：
10.1016/j.ceb.2013.11.003
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发表时间：
2014-02
影响因子：
7.5
通讯作者：
Naethke, Inke
中科院分区：
文献类型：
--
作者：
Hinck, Lindsay;Naethke, Inke
大多数癌症发生在上皮细胞中，上皮细胞是所有体腔的组织类型。上皮细胞的组织使它们能够充当屏障，并在身体隔室之间进行分子的矢量运输。对于它们的组织和功能至关重要的是一个高度特化的细胞粘附和极性蛋白质网络，该网络沿顶基轴沿着。比较乳腺和肠组织作为常见癌症部位的例子，揭示了极性蛋白对癌症的发生和发展的重要贡献。极性缺陷直接由极性蛋白的突变引起，但也间接由特定microRNA表达的变化和改变的转录程序引起，这些转录程序驱动细胞从上皮分化为更具间充质特征。后者在转移过程中尤为重要。
Most cancers arise in epithelia, the tissue type that lines all body cavities. The organization of epithelia enables them to act as a barrier and perform vectorial transport of molecules between body compartments. Crucial for their organization and function is a highly specialized network of cell adhesion and polarity proteins aligned along the apical – basal axis. Comparing breast and intestinal tissue as examples of common cancer sites, reveals an important contribution of polarity proteins to the initiation and progression of cancer. Defects in polarity are induced directly by mutations in polarity proteins, but also indirectly by changes in the expression of specific microRNAs and altered transcriptional programs that drive cellular differentiation from epithelial to more mesenchymal characteristics. The latter is particularly important in the metastatic process.
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影响因子：
7.3
作者：
Kim NH;Kim HS;Kim NG;Lee I;Choi HS;Li XY;Kang SE;Cha SY;Ryu JK;Na JM;Park C;Kim K;Lee S;Gumbiner BM;Yook JI;Weiss SJ
通讯作者：
Weiss SJ
MicroRNA-212 的遗传和表观遗传下调通过 MnSOD 失调促进结直肠肿瘤转移
影响因子：
29.4
作者：
Meng, Xiangqi;Wu, Jiangxue;Huang, Wenlin
通讯作者：
Huang, Wenlin
DOI：
10.1073/pnas.1108977108
发表时间：
2011-11-29
影响因子：
11.1
作者：
Sanchez-Tillo, Ester;de Barrios, Oriol;Postigo, Antonio
通讯作者：
Postigo, Antonio
影响因子：
4.6
作者：
Hou, Han Wei;Warkiani, Majid Ebrahimi;Khoo, Bee Luan;Li, Zi Rui;Soo, Ross A.;Tan, Daniel Shao-Weng;Lim, Wan-Teck;Han, Jongyoon;Bhagat, Ali Asgar S.;Lim, Chwee Teck
通讯作者：
Lim, Chwee Teck
DOI：
10.1258/ebm.2011.011007
发表时间：
2011-05-01
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Jochems C;Schlom J
通讯作者：
Schlom J