Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity.
Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity.
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DOI：
10.1258/ebm.2011.011007
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发表时间：
2011-05-01
期刊：
影响因子：
--
通讯作者：
Schlom J
中科院分区：
文献类型：
--
作者：
Jochems C;Schlom J
许多研究已经证明了几种人类癌症类型中的免疫浸润与预后和对治疗的反应之间的联系。这些研究中最全面的是结直肠癌，许多研究组得出了类似的结论。对其他几种癌症类型的免疫浸润的分析也显示了免疫浸润和预后之间的一般相关性，但有一些相互矛盾的结果。本综述将试图总结这一领域的现状，并指出哪些因素可能导致一些相互矛盾的发现。尽管如此，对于某些癌细胞类型得出类似结论的报告的广度导致人们更认真地考虑免疫细胞浸润与肿瘤预后和/或对治疗的反应之间的联系，以及将常规癌症治疗与采用治疗性癌症疫苗的主动免疫治疗相结合的潜力。
Numerous studies have now documented a link between the immune infiltrate in several human carcinoma types and prognosis and response to therapy. The most comprehensive of these studies were in colorectal cancer with similar conclusions by numerous groups. Analyses of immune infiltrate of several other carcinoma types also showed general correlations between immune infiltrate and prognosis, but with some conflicting results. This review will attempt to summarize the current state of this field and point out what factors may be responsible for some of the conflicting findings. Nonetheless, the breadth of reports drawing similar conclusions for some cancer cell types leads one to more seriously consider the link between immune cell infiltrate and tumor prognosis and/or response to therapy, and the potential for combining conventional cancer therapy with active immunotherapy employing therapeutic cancer vaccines.
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影响因子：
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DOI：
10.1097/cji.0b013e3181d32f01
发表时间：
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期刊：
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