An Ultrastructural Study of the Retention Hyperkeratosis of Experimentally Induced Comedones in Rabbits: The Effects of Three Comedolytics
An Ultrastructural Study of the Retention Hyperkeratosis of Experimentally Induced Comedones in Rabbits: The Effects of Three Comedolytics
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家兔实验性粉刺残留角化过度的超微结构研究：三种粉刺溶解剂的作用
DOI：
10.1111/j.1346-8138.1996.tb03993.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. Myung
中科院分区：
文献类型：
--
作者：
C. Oh;K. Myung
The precise pathologic processes of comedo formation in acne are not well understool. Retention hyperkeratosis may play an important role. To evaluate the effects of three topical comedolytics, 20% azelaic acid, 0.1% tretinoin and 5% benzoyl peroxide, on the retention hyperkeratosis of experimentally induced comedones (EIC), an ultrastructural study was done. After formation of EIC with 50% oleic acid in paraffin oil on the external ears of rabbits, each comedolytic was applied for 4 weeks. Biopsies were taken every week and, using a Hitachi H‐600 transmission electron microscope, morphologic observations were done in the upper portion of the follicular epithelium. In EIC, after application of each comedolytic, the markedly thinned horny layer was loosely adhered by extremely few desmosomes and desmosomal bodies. The number and size of tonofilaments and keratohyaline granules decreased, but the number of variable sized Odland bodies increased in the upper epidermis. These findings appeared 1 week after application of either azelaic acid or benzoyl peroxide, and 3 weeks after application of tretinoin. For the first 2 weeks of tretinoin application, EIC showed rather compact hyperkeratosis with more desmosomes and desmosomal bodies than before. Azelaic acid tretinoin and benzoyl peroxide increased the number of Odland bodies, and the horny cells became less adhesive. This lysis of retention hyperkeratosis resulted in comedolysis. During 4 weeks of treatment with these three comedolytics, only tretinoin normalized the keratinization process.
DOI：
--
发表时间：
1986-04
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
M. Connor;R. Ashton;N. Lowe
通讯作者：
M. Connor;R. Ashton;N. Lowe
哺乳动物角质层细胞间脂质层的分子模型。
DOI：
10.1111/1523-1747.ep12276794
发表时间：
1989
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Swartzendruber,DC;Wertz,PW;Kitko,DJ;Madison,KC;Downing,DT
通讯作者：
Downing,DT
影响因子：
6.5
作者：
FREINKEL, RK;TRACZYK, TN
通讯作者：
TRACZYK, TN