Overexpression of hyaluronan-binding protein 1 promotes the proliferation, migration, and invasion of malignant glioma.
Overexpression of hyaluronan-binding protein 1 promotes the proliferation, migration, and invasion of malignant glioma.
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透明质酸结合蛋白1的过度表达促进恶性胶质瘤的增殖、迁移和侵袭
DOI：
10.21037/tcr.2019.11.01
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发表时间：
2020-01
影响因子：
0.9
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Yang Z;Song S;Yin W;Qian X;Yu Q;Wang D
背景透明质酸结合蛋白1（HABP1）是透明质酸粘附素家族的成员，参与T细胞活化。它是一种高级多糖。CD44家族也是这个家族的一员。它在许多肿瘤细胞中的表达水平高于相应的正常组织。它与肿瘤细胞的发生、发展、侵袭和淋巴结转移有关。然而，HABP1在胶质瘤中的作用机制尚不清楚。方法研究HABP1在胶质瘤中的增殖和侵袭能力。采用免疫组化方法检测HABP1在80例不同级别胶质瘤组织中的表达。然后，通过不同的人胶质瘤细胞系模型的迁移和增殖的影响进行了研究。结果通过收集大量的临床病理组织和患者资料，发现HABP1的表达与胶质瘤显著相关，并通过不同的胶质瘤细胞系筛选出HABP1高表达和低表达的凝胶。在细胞形态学分析中，HABP1的短干扰RNA显著抑制胶质瘤的增殖，HABP1的过表达促进胶质瘤的侵袭和迁移。结论HABP1有可能成为胶质瘤治疗的新靶向因子。HABP1在胶质瘤中的作用机制有待进一步研究。
Background Hyaluronan binding protein 1 (HABP1) is a member of the hyaladherin family and is involved in T cell activation. It is a high-grade polysaccharide. The CD44 family is also a member of this family. It is expressed in many tumor cells at higher levels than the corresponding normal tissues. It is related to the occurrence and development of tumor cells, invasiveness, and lymph node metastasis. However, the mechanism of HABP1 in glioma remains unclear. Methods We focused on the proliferation and invasion of HABP1 in gliomas. The expression of HABP1 was firstly investigated by immunohistochemical staining and by comparing different grades of glioma tissues from 80 patients with glioma. Then, the influence of migration and proliferation through different human glioma cell line models were investigated. Results By collecting a large number of clinical pathological tissues and patient data, it was found that HABP1 expression was significantly correlated with glioma, and gels with a high expression of HABP1 and a low expression of HABP1 were screened by different glioma cell lines. In the cytomorphological analysis, short interfering RNA with HABP1 significantly inhibited the proliferation of glioma, and the overexpression of HABP1 enhanced glioma invasion and migration. Conclusions HABP1 is likely to become a new targeting factor for the treatment of glioma. The mechanism of action of HABP1 in glioma remains to be further studied.
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影响因子：
3.6
作者：
Applebaum AJ;Buda K;Kryza-Lacombe M;Buthorn JJ;Walker R;Shaffer KM;D'Agostino TA;Diamond EL
通讯作者：
Diamond EL
影响因子：
6.7
作者：
Biswas AK;Hafiz A;Banerjee B;Kim KS;Datta K;Chitnis CE
通讯作者：
Chitnis CE
纠正对复发性神经胶质瘤重新辐照的专家共识。
DOI：
10.1186/s13014-018-0955-8
发表时间：
2018-01-18
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Krauze AV;Attia A;Braunstein S;Chan M;Combs SE;Fietkau R;Fiveash J;Flickinger J;Grosu A;Howard S;Nieder C;Niyazi M;Rowe L;Smart DD;Tsien C;Camphausen K
通讯作者：
Camphausen K
鸡胸肌和大腿组织肌内脂肪代谢差异表达基因及通路鉴定
影响因子：
4.4
作者：
Cui H;Zheng M;Zhao G;Liu R;Wen J
通讯作者：
Wen J
影响因子：
--
作者：
Preca BT;Bajdak K;Mock K;Lehmann W;Sundararajan V;Bronsert P;Matzge-Ogi A;Orian-Rousseau V;Brabletz S;Brabletz T;Maurer J;Stemmler MP
通讯作者：
Stemmler MP